← Statins × pharmacokinetics & dosing

SynthesisMedicine2018

Statins use and risk of dementia: A dose-response meta analysis.

Xiaoyu Zhang et al.PubMed ↗Full text ↗Publisher ↗

What moved togetherboth groups pooled, not the treatment’s effect

Correlation, not cause

Went with lower pharmacokinetics & dosing

−20%−27% to −13%

Bigger than 4 in 10 on the map

As reported

RR 0.80, 95% CI 0.73–0.87

Correlation, not cause

Went with lower pharmacokinetics & dosing

−11%−17% to −4%

Bigger than 2 in 10 on the map

As reported

RR 0.89, 95% CI 0.83–0.96

Two numbers in the abstract

the abstract, start to end

… with 20% dementia risk decrement (RR: 0.80; 95% CI, 0.73-0.87), and per 5-mg mean daily dose incremental increase in statins use was associated with 11% dementia risk decrement (RR: 0.89; 95% CI, 0.83-0.96).

← favours treatmentfavours comparator →
could be chance
Pharmacokinetics & dosing
RR 0.800.73–0.87
Pharmacokinetics & dosing
RR 0.890.83–0.96
StatinsPharmacokinetics & dosing
1 / 3

44 papers cite it

2018
2019
2020
2021
2022
2023
2024
2025
2026
this paperpooled itcites it
Full record →Abstract, authors, funding and every citing paper · PMID 30045255