← Metformin × all-cause mortality

SynthesisMedicine2018

Association of metformin intake with bladder cancer risk and oncologic outcomes in type 2 diabetes mellitus patients: A systematic review and meta-analysis.

Jiao Hu et al.PubMed ↗Full text ↗Publisher ↗

What moved togetherboth groups pooled, not the treatment’s effect

Correlation, not cause

Went with fewer deaths

−45%−65% to −12%

Bigger than 9 in 10 for all-cause mortality

As reported

HR 0.55, 95% CI 0.35–0.88 · the paper's word: All-cause mortality

Correlation, not cause

Went with fewer deaths

−30%−49% to −4%

Bigger than 8 in 10 for all-cause mortality

As reported

HR 0.70, 95% CI 0.51–0.96 · the paper's word: All-cause mortality

Correlation, not cause

Went with fewer deaths

−43%−60% to −19%

Bigger than 9 in 10 for all-cause mortality

As reported

HR 0.57, 95% CI 0.40–0.81 · the paper's word: All-cause mortality

+7 more in the walkthrough ↓

Ten numbers in the abstract

the abstract, start to end

… increased recurrence-free survival (HR = 0.55, 95% confidence interval [CI] = 0.35-0.88; P = .01; I = 64%), improved progression-free survival (HR = 0.70, 95% CI = 0.51-0.96; P = .03; I = 33%), and prolonged cancer-specific survival (HR = 0.57, 95% CI = 0.40-0.81; P = .002; …

… incidence of bladder cancer (HR = 0.82, 95% CI = 0.61-1.09; P = .17; I = 85%) or an increased overall survival in bladder cancer patients (HR = 0.83, 95% CI = 0.47-1.44; P = .50; …

… an increased RFS of bladder cancer (HR = 0.55, 95% CI = 0.35-0.88; P = .01).

… an increased CSS of bladder cancer (HR = 0.57, 95% CI = 0.40-0.81; P = .002) …

… an increased PFS of bladder cancer (HR = 0.70, 95% CI = 0.51-0.96; P = .03) …

… incidence of bladder cancer (HR = 0.82, 95% CI = 0.61-1.09; P = .17).

… use and OS of bladder cancer (HR = 0.83, 95% CI = 0.47-1.44; P = .50) …

← favours treatmentfavours comparator →
could be chance
All-cause mortality
HR 0.550.35–0.88
All-cause mortality
HR 0.700.51–0.96
All-cause mortality
HR 0.570.40–0.81
Adverse events & safety
HR 0.820.61–1.09
All-cause mortality
HR 0.830.47–1.44
Adverse events & safety
HR 0.550.35–0.88
Adverse events & safety
HR 0.570.40–0.81
Adverse events & safety
HR 0.700.51–0.96
Adverse events & safety
HR 0.820.61–1.09
Adverse events & safety
HR 0.830.47–1.44
MetforminAll-cause mortalityAdverse events & safety
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Full record →Abstract, authors, funding and every citing paper · PMID 30045293