GLP-1 receptor agonists × blood pressure

TrialDiabetes, obesity & metabolism2019

Effect of liraglutide on ambulatory blood pressure in patients with hypertension and type 2 diabetes: A randomized, double-blind, placebo-controlled trial.

Aris Liakos et al.PubMed ↗Publisher ↗

What the trial testedrandomised · 87 people · 2019

Randomised comparison

Probably lowered adverse events & safety

−5.73mm Hg−9.81 to −1.65

As reported

difference −5.73 mm Hg, 95% CI −9.81 to −1.65

Range includes no effect

No clear effect on blood pressure

−1.42mm Hg−4.25 to +1.40

As reported

difference −1.42 mm Hg, 95% CI −4.25 to 1.40

Two numbers in the abstract

the abstract, start to end

liraglutide reduced 24-hour SBP by -5.73 mm Hg (95% confidence interval [CI] -9.81 to -1.65) and had a neutral effect on 24-hour DBP (mean difference - 1.42 mm Hg; 95% CI -4.25 to 1.40),

← favours treatmentfavours comparator →
could be chance
Adverse events & safety
−5.73−9.81 to −1.65
Blood pressure
−1.42−4.25 to 1.40
GLP-1 receptor agonistsBlood pressureAdverse events & safety

GLP-1 receptor agonists × blood pressurehelps?mixed

unlikelylikely
0.500.50 without it

GLP-1 receptor agonists × adverse events & safetyharms?mixed

unlikelylikely
0.020.02 without it
← favours treatmentfavours comparator →
this papermore certainless certain
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Full record →Abstract, authors, funding and every citing paper · PMID 30242948