DPP-4 inhibitors × glycemic control

TrialJAMA2019

Effect of Additional Oral Semaglutide vs Sitagliptin on Glycated Hemoglobin in Adults With Type 2 Diabetes Uncontrolled With Metformin Alone or With Sulfonylurea: The PIONEER 3 Randomized Clinical Trial.

Julio Rosenstock et al.PubMed ↗Full text ↗Publisher ↗

What the trial testedas reported · 2,463 people · 2019

Not counted

Lowered glycemic control

−0.30percentage points−0.40 to −0.10

As reported

difference −0.3 %, 95% CI −0.40 to −0.10

Not counted

Lowered body weight & composition

−1.60kg−2.00 to −1.10

As reported

difference −1.6 kg, 95% CI −2.00 to −1.10

Two numbers in the abstract

the abstract, start to end

reduced HbA1c (differences, -0.3% [95% CI, -0.4% to -0.1%] and -0.5% [95% CI, -0.6% to -0.4%], respectively; P < .001 for both) and body weight (differences, -1.6 kg [95% CI, -2.0 to -1.1 kg]

← favours treatmentfavours comparator →
could be chance
Glycemic control
−0.3−0.40 to −0.10
Body weight & composition
−1.6−2.00 to −1.10
GLP-1 receptor agonistsDPP-4 inhibitorsGlycemic controlBody weight & composition
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The trial

Full record →Abstract, authors, funding and every citing paper · PMID 30903796