Evidence map›Paper›PMID 30934586›Full record

ReviewAntioxidants (Basel, Switzerland)2019

Measurement and Clinical Significance of Lipid Peroxidation as a Biomarker of Oxidative Stress: Oxidative Stress in Diabetes, Atherosclerosis, and Chronic Inflammation.

Fumiaki Ito, Yoko Sono, Tomoyuki Ito

Open access · goldAbstract readReview
In one paragraph

Review in Antioxidants (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 239 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
239citing papers in PubMed, 7 pooled it
32.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

239 citing papers in PubMed, 7 syntheses or guidelines pooled it, 495 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Trial
  9. Trial
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Antioxidant and Tyrosinase Inhibitory Potential ofJournal of pharmacopuncture · 2026
    Article
  17. Article
  18. Total Flavonoids fromAntioxidants (Basel, Switzerland) · 2026
    Article
  19. Review
  20. Article

179 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Fumiaki ItoThe Institute of Prophylactic Pharmacology, Shinagawa, Tokyo 140-0001, Japan. setsunanfi@zmail.plala.or.jp.
Yoko SonoR&D Department, Sunstar Inc., Takatsuki, Osaka 569-1195, Japan. yoko.sono@jp.sunstar.com.
Tomoyuki ItoPhysical Medicine and Rehabilitation, Tanabe Memorial Hospital, Kyotanabe-City, Kyoto 610-0331, Japan. rinito@par.odn.ne.jp.
Kyoto Prefectural University of Medicine · JPSunstar (Japan) · JP

Funding

Japan Society for the Promotion of Science 15K01383
6 · The paper itself

Abstract

Endothelial dysfunction is one of the initial steps in the pathogenesis of atherosclerosis and development of cardiovascular disease in patients with diabetes mellitus. Several risk factors are associated with endothelial dysfunction and atherosclerosis, such as hypertension, dyslipidaemia, inflammation, oxidative stress, and advanced glycation-end products. Among these risk factors, oxidative stress is the largest contributor to the formation of atherosclerotic plaques. Measurement of reactive oxygen species (ROS) is still difficult, and assays for the measurement of ROS have failed to show a consistent correlation between pathological states and oxidative stress. To solve this problem, this review summarizes the current knowledge on biomarkers of oxidative stress, especially lipid peroxidation, and discusses the roles of oxidative stress, as measured by indices of lipid peroxidation, in diabetes mellitus, atherosclerosis, and chronic inflammation.

Indexed as

8-isoprostaglandin F2αatherosclerosiscardiovascular diseasechronic inflammationdiabetes mellitusendothelial dysfunctionFe-ROMs testlipid peroxidationmalondialdehydeoxidative stressoxidative stress biomarkersoxidized high-density lipoprotein

Identifiers

PMID30934586
PMCPMC6466575
OpenAlexW2924534120

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.