Evidence map›Paper›PMID 31072245›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2019

Benzonate derivatives of acetophenone as potent α-glucosidase inhibitors: synthesis, structure-activity relationship and mechanism.

Wen-Jia Dan, Qiang Zhang, Fan Zhang, Wei-Wei Wang, Jin-Ming Gao

Open access · goldAbstract read
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Wen-Jia Dana Shaanxi Key Laboratory of Natural Products and Chemical Biology, College of Chemistry and Pharmacy , Northwest A&F University , Yangling , Shaanxi , China.
Qiang Zhanga Shaanxi Key Laboratory of Natural Products and Chemical Biology, College of Chemistry and Pharmacy , Northwest A&F University , Yangling , Shaanxi , China.
Fan Zhanga Shaanxi Key Laboratory of Natural Products and Chemical Biology, College of Chemistry and Pharmacy , Northwest A&F University , Yangling , Shaanxi , China.
Wei-Wei Wanga Shaanxi Key Laboratory of Natural Products and Chemical Biology, College of Chemistry and Pharmacy , Northwest A&F University , Yangling , Shaanxi , China.
Jin-Ming Gaoa Shaanxi Key Laboratory of Natural Products and Chemical Biology, College of Chemistry and Pharmacy , Northwest A&F University , Yangling , Shaanxi , China.
Northwest A&F University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this article, 23 compounds (6 and 7a-7v) were prepared and evaluated for their in vitro α-glucosidase inhibitory activity. The compounds 7d, 7f, 7i, 7n, 7o, 7r, 7s, 7u, and 7v displayed the α-glucosidase inhibition activity with IC

Indexed as

Acetophenonesalpha-GlucosidasesDose-Response Relationship, DrugGlycoside Hydrolase InhibitorsHumansMolecular StructureStructure-Activity RelationshipThermodynamics2,4-dihydroxy-5-methylacetophenoneAcetophenonesalpha-GlucosidasesGlycoside Hydrolase Inhibitorsacetophenone derivativesinhibiting mechanismα-Glucosidase

Identifiers

PMID31072245
PMCPMC6522914
OpenAlexW2943905346

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.