Evidence map›Paper›PMID 31292453›Full record

ArticleNature communications2019

Decreased maternal serum acetate and impaired fetal thymic and regulatory T cell development in preeclampsia.

Mingjing Hu, David Eviston, Peter Hsu, Eliana Mariño, Ann Chidgey, Brigitte Santner-Nanan, Kahlia Wong, James L Richards, Yu Anne Yap, Fiona Collier and 15 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
95citing papers in PubMed, 4 pooled it
21.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

95 citing papers in PubMed, 4 syntheses or guidelines pooled it, 151 citations in OpenAlex.

  1. Pooled it
  2. Advances in pathogenesis of preeclampsia.Archives of gynecology and obstetrics · 2024
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. Review
  11. Lipid metabolism in homeostasis and disease.Signal transduction and targeted therapy · 2026
    Review
  12. Review
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Review
  19. Review
  20. Review

35 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

25 authors at 12 institutions in 1 country.

Mingjing HuCharles Perkins Centre Nepean, The University of Sydney, Penrith, 2750, NSW, Australia.ORCID http://orcid.org/0000-0002-0104-2072
David EvistonSydney Medical School Nepean, The University of Sydney, Penrith, 2750, NSW, Australia.
Peter HsuDiscipline of Paediatrics and Child Health, Sydney Medical School, The University of Sydney, Sydney, 2006, NSW, Australia.
Eliana MariñoInfection and Immunity Program, Biomedicine Discovery Institute, Monash University, Clayton, 3800, VIC, Australia.ORCID http://orcid.org/0000-0001-5371-8778
Ann ChidgeyDepartment of Anatomy and Developmental Biology, Biomedicine Discovery Institute, Monash University, Clayton, 3800, VIC, Australia.
Brigitte Santner-NananCharles Perkins Centre Nepean, The University of Sydney, Penrith, 2750, NSW, Australia.
Kahlia WongDepartment of Anatomy and Developmental Biology, Biomedicine Discovery Institute, Monash University, Clayton, 3800, VIC, Australia.
James L RichardsInfection and Immunity Program, Biomedicine Discovery Institute, Monash University, Clayton, 3800, VIC, Australia.
Yu Anne YapInfection and Immunity Program, Biomedicine Discovery Institute, Monash University, Clayton, 3800, VIC, Australia.
Fiona CollierDeakin University, Geelong, 3220, VIC, Australia.
Ann QuintonSydney Medical School Nepean, The University of Sydney, Penrith, 2750, NSW, Australia.ORCID http://orcid.org/0000-0001-6585-7468
Steven JoungSydney Medical School Nepean, The University of Sydney, Penrith, 2750, NSW, Australia.
Michael PeekSydney Medical School Nepean, The University of Sydney, Penrith, 2750, NSW, Australia.ORCID http://orcid.org/0000-0001-6055-5129
Ron BenzieNepean Hospital, Penrith, 2750, NSW, Australia.
Laurence MaciaDepartment of Pathology, School of Medical Sciences, Charles Perkins Centre, The University of Sydney, Sydney, 2006, NSW, Australia.
David WilsonCentre for Molecular Therapeutics, AITHM, James Cook University, Cairns, 4814, QLD, Australia.
Ann-Louise PonsonbyMurdoch Children's Research Institute, Parkville, 3052, VIC, Australia.
Mimi L K TangMurdoch Children's Research Institute, Parkville, 3052, VIC, Australia.ORCID http://orcid.org/0000-0002-3839-5293
Martin O'HelyDeakin University, Geelong, 3220, VIC, Australia.
Norelle L DalyCentre for Molecular Therapeutics, AITHM, James Cook University, Cairns, 4814, QLD, Australia.
Charles R MackayInfection and Immunity Program, Biomedicine Discovery Institute, Monash University, Clayton, 3800, VIC, Australia.ORCID http://orcid.org/0000-0002-6338-7340
Jane E DahlstromAnatomical Pathology, ACT Pathology, Canberra Hospital and ANU Medical School, College of Health and Medicine, The Australian National University, Canberra, 0200, ACT, Australia.
BIS Investigator Group
Peter VuillerminDeakin University, Geelong, 3220, VIC, Australia.
Ralph NananCharles Perkins Centre Nepean, The University of Sydney, Penrith, 2750, NSW, Australia. ralph.nanan@sydney.edu.au.
The University of Sydney · AUAustralian Regenerative Medicine Institute · AUMurdoch Children's Research Institute · AUAustralian National University · AUAustralian Institute of Tropical Health and Medicine · AUNepean Hospital · AUThe University of Queensland · AUBarwon Health · AUDeakin University · AURoyal Children's Hospital · AUThe George Institute for Global Health · AUWalter and Eliza Hall Institute of Medical Research · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Maternal immune dysregulation seems to affect fetal or postnatal immune development. Preeclampsia is a pregnancy-associated disorder with an immune basis and is linked to atopic disorders in offspring. Here we show reduction of fetal thymic size, altered thymic architecture and reduced fetal thymic regulatory T (Treg) cell output in preeclamptic pregnancies, which persists up to 4 years of age in human offspring. In germ-free mice, fetal thymic CD4

Indexed as

AcetatesAdultAIRE ProteinAnimalsAnimals, NewbornCase-Control StudiesChild DevelopmentChild, PreschoolDietary SupplementsFemaleFetusGastrointestinal MicrobiomeGerm-Free LifeHumansImmune ToleranceInfantAcetatesAIRE ProteinTranscription Factors

Identifiers

PMID31292453
PMCPMC6620275
OpenAlexW2962483049

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.