Evidence mapPaperPMID 31467327Full record

ArticleScientific reports2019

Circulating but not faecal short-chain fatty acids are related to insulin sensitivity, lipolysis and GLP-1 concentrations in humans.

Mattea Müller, Manuel A González Hernández, Gijs H Goossens, Dorien Reijnders, Jens J Holst, Johan W E Jocken, Hans van Eijk, Emanuel E Canfora, Ellen E Blaak

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04887584 (Identifying the Role of Pulses in a Healthful Diet), which is not on this map. Cited by 163 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
163citing papers in PubMed, 5 pooled it
21.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04887584 nacompletednot on this mapstarted 2022, after this paper: background citation

Identifying the Role of Pulses in a Healthful Diet: Metabolomic Signatures of Dietary Pulses and Their Benefits on Cardiometabolic Risk Factors

TypeinterventionalSponsorUSDA, Western Human Nutrition Research CenterRan2022 to 2023Enrolled20ConditionsBody WeightArmsControl diet, Low Pulse diet, High Pulse diet
3 · Its place in the literature

Who cites it

163 citing papers in PubMed, 5 syntheses or guidelines pooled it, 317 citations in OpenAlex.

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  8. Testosterone administration partially modulates gut microbiota responses to severe energy deficit.American journal of physiology. Endocrinology and metabolism · 2026
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103 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Mattea MüllerDepartment of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, The Netherlands.ORCID http://orcid.org/0000-0002-3340-5122
Manuel A González HernándezDepartment of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, The Netherlands.
Gijs H GoossensDepartment of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, The Netherlands.
Dorien ReijndersDepartment of Pediatrics, Maastricht University Medical Centre+, Maastricht, The Netherlands.
Jens J HolstNNF Center for Basic Metabolic Research and Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Johan W E JockenDepartment of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, The Netherlands.
Hans van EijkDepartment of Surgery, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center+, Maastricht, The Netherlands.ORCID http://orcid.org/0000-0001-5033-9537
Emanuel E CanforaDepartment of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, The Netherlands.ORCID http://orcid.org/0000-0003-0267-1097
Ellen E BlaakDepartment of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, The Netherlands. e.blaak@maastrichtuniversity.nl.ORCID http://orcid.org/0000-0002-2496-3464
Maastricht University Medical Centre · NLMaastricht University · NLUniversity of Copenhagen · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microbial-derived short-chain fatty acids (SCFA) acetate, propionate and butyrate may provide a link between gut microbiota and whole-body insulin sensitivity (IS). In this cross-sectional study (160 participants, 64% male, BMI: 19.2-41.0 kg/m

Indexed as

Insulin ResistanceAdultAgedCross-Sectional StudiesFatty Acids, VolatileFecesFemaleGastrointestinal MicrobiomeGlucagon-Like Peptide 1HumansInsulinLipolysisMaleMiddle AgedYoung AdultFatty Acids, VolatileGlucagon-Like Peptide 1Insulin

Identifiers

PMID31467327
PMCPMC6715624
OpenAlexW2970182432

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.