Evidence map›Paper›PMID 31781670›Full record

SynthesisJournal of diabetes research2019

Comparative Efficacy and Safety of Metformin, Glyburide, and Insulin in Treating Gestational Diabetes Mellitus: A Meta-Analysis.

Lanlan Guo, Jing Ma, Jia Tang, Dingyao Hu, Wei Zhang, Xue Zhao

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of diabetes research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 7 pooled it
15.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 7 syntheses or guidelines pooled it, 137 citations in OpenAlex.

  1. Pooled it
  2. Metformin + Insulin vs. Insulin for GDM and T2DM during pregnancy: systematic review and meta-analysis.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2026 · on this map
    Pooled it
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  8. Trial
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  12. Molecules (Basel, Switzerland) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 6 institutions in 1 country.

Lanlan GuoDepartment of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China.
Jing MaDepartment of Endocrinology and Metabolism, Gansu Provincial Hospital, Lanzhou 730000, China.ORCID https://orcid.org/0000-0001-6159-0209
Jia TangDepartment of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai 200041, China.
Dingyao HuThe Second Clinical Medical College, Lanzhou University, Lanzhou 730000, China.
Wei ZhangDepartment of Critical Care Medicine, Affiliated Hospital of Zunyi Medical College, Zunyi 563000, China.
Xue ZhaoDepartment of Nephrology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, China.
Affiliated Hospital of Zunyi Medical College · CNFudan University · CNGansu Provincial Hospital · CNLanzhou University Second Hospital · CNShandong University · CNSun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To compare the efficacy and safety of metformin, glyburide, and insulin in treating gestational diabetes mellitus (GDM), a meta-analysis of randomized controlled trials (RCTs) was conducted. PubMed, Embase, CINAHL, Web of Science, and Cochrane Library to November 13, 2018, were searched for RCT adjusted estimates of the efficacy and safety of metformin, glyburide, and insulin treatments in GDM patients. There were 41 studies involving 7703 GDM patients which were included in this meta-analysis; 12 primary outcomes and 24 secondary outcomes were detected and analyzed. Compared with metformin, insulin had a significant increase in the risk of preeclampsia (RR, 0.57; 95% CI, 0.45 to 0.72;

Indexed as

AdultBiomarkersBlood GlucoseDiabetes, GestationalFemaleGlyburideHumansHypoglycemic AgentsInsulinMetforminPatient SafetyPregnancyRandomized Controlled Trials as TopicRisk AssessmentTreatment OutcomeYoung AdultBiomarkersBlood GlucoseGlyburideHypoglycemic AgentsInsulinMetformin

Identifiers

PMID31781670
PMCPMC6875019
OpenAlexW2988065151

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.