Evidence map›Paper›PMID 32316181›Full record

ReviewNutrients2020

The Effect of Probiotics on the Production of Short-Chain Fatty Acids by Human Intestinal Microbiome.

Paulina Markowiak-Kopeć, Katarzyna Śliżewska

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06432608 (Single Arm Study to Evaluate the Efficacy of Lacticaseibacillus Paracasei Strain Shirota), which is not on this map. Cited by 614 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
614citing papers in PubMed, 5 pooled it
56.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06432608 naunknown statusnot on this mapstarted 2024, after this paper: background citation

Single Arm Study to Evaluate the Efficacy of Lacticaseibacillus Paracasei Strain Shirota (Formerly Lactobacillus Casei Strain Shirota) Fermented Milk (Yakult®) on the Maintenance of Clinical Manifestations of Functional Constipation in Mexican Adults

TypeinterventionalSponsorUniversity of GuadalajaraRan2024 to 2025Enrolled50ConditionsConstipationArmsfermented milk, Yakult
3 · Its place in the literature

Who cites it

614 citing papers in PubMed, 5 syntheses or guidelines pooled it, 1,107 citations in OpenAlex.

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  8. [Preventive effect ofZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026
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554 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Paulina Markowiak-KopećInstitute of Fermentation Technology and Microbiology, Department of Biotechnology and Food Sciences, Lodz University of Technology, 90-924 Łódź, Poland.
Katarzyna ŚliżewskaInstitute of Fermentation Technology and Microbiology, Department of Biotechnology and Food Sciences, Lodz University of Technology, 90-924 Łódź, Poland.
Lodz University of Technology · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The relationship between diet and the diversity and function of the intestinal microbiome and its importance for human health is currently the subject of many studies. The type and proportion of microorganisms found in the intestines can determine the energy balance of the host. Intestinal microorganisms perform many important functions, one of which is participation in metabolic processes, e.g., in the production of short-chain fatty acids-SCFAs (also called volatile fatty acids). These acids represent the main carbon flow from the diet to the host microbiome. Maintaining intestinal balance is necessary to maintain the host's normal health and prevent many diseases. The results of many studies confirm the beneficial effect of probiotic microorganisms on the balance of the intestinal microbiome and produced metabolites, including SCFAs. The aim of this review is to summarize what is known on the effects of probiotics on the production of short-chain fatty acids by gut microbes. In addition, the mechanism of formation and properties of these metabolites is discussed and verified test results confirming the effectiveness of probiotics in human nutrition by modulating SCFAs production by intestinal microbiome is presented.

Indexed as

DietBifidobacteriumCarbonChronic DiseaseFatty Acids, VolatileGastrointestinal MicrobiomeHost Microbial InteractionsHumansLactic AcidLactobacillusNutritional Physiological PhenomenaProbioticsCarbonFatty Acids, VolatileLactic Acidhuman healthintestinal microbiomemetabolites of bacteriaprobioticsSCFA

Identifiers

PMID32316181
PMCPMC7230973
OpenAlexW3016467539

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.