SGLT2 inhibitors × cardiac & vascular function

TrialESC heart failure2020

Effects of canagliflozin in patients with type 2 diabetes and chronic heart failure: a randomized trial (CANDLE).

Atsushi Tanaka et al.PubMed ↗Full text ↗Publisher ↗

  • Canagliflozinno clear effectNo clear effect on NT-proBNP levels.Nothing cleared the noise.

What the trial testedas reported · 233 people · 2020

Range includes no effect

No clear effect on NT-proBNP levels

−74.7pg/mL−159 to +10.9

canagliflozin vs glimepiride

As reported

difference −74.7 pg/mL, 95% CI −159 to 10.9

Range includes no effect

No clear effect on NT-proBNP levels

−58.3−128 to +11.0

canagliflozin vs glimepiride, in preserved LVEF

As reported

difference −58.3, 95% CI −128 to 11.0

Who was studied, and how

233people with type 2 diabetes, in this paper

The trial randomly assignedassigned by chance

canagliflozin
glimepiride

No clear effect on NT-proBNP levels−74.7

randomised

Among preserved LVEF, the trial randomly assignedassigned by chance

canagliflozin
glimepiride

No clear effect on NT-proBNP levels−58.3

randomised

the abstract, start to end

group [adjusted group difference; -74.7 pg/mL (95% CI, -159.3 to 10.9), P = 0.087] and also in the subgroup with preserved LVEF [-58.3 (95% CI, -127.6 to 11.0, P =

← favours treatmentfavours comparator →
could be chance
NT-proBNP levelscanagliflozin vs glimepiride
−74.7−159 to 10.9
NT-proBNP levelscanagliflozin vs glimepiride, in preserved LVEF
−58.3−128 to 11.0
SGLT2 inhibitorsCardiac & vascular function
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Full record →Abstract, authors, funding and every citing paper · PMID 32349193