Evidence map›Paper›PMID 32514366›Full record

ArticleFungal biology and biotechnology2020

Functional production of human antibody by the filamentous fungus

Hung Hiep Huynh, Naoki Morita, Toshihiro Sakamoto, Takuya Katayama, Takuya Miyakawa, Masaru Tanokura, Yasunori Chiba, Reiko Shinkura, Jun-Ichi Maruyama

Open access · goldAbstract read
In one paragraph

Article in Fungal biology and biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 30 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Large-Scale Production of Anti-RNase A VHH Expressed inCurrent issues in molecular biology · 2023
    Article
  10. CRISPR/Cas9-Based Genome Editing and Its Application inJournal of fungi (Basel, Switzerland) · 2022
    Review
  11. Review
  12. Membrane Traffic inJournal of fungi (Basel, Switzerland) · 2021
    Review
  13. Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Hung Hiep HuynhDepartment of Biotechnology, The University of Tokyo, Tokyo, Japan.
Naoki MoritaLaboratory of Immunology and Infection Control, Institute for Quantitative Biosciences, The University of Tokyo, Tokyo, Japan.
Toshihiro SakamotoLaboratory of Immunology and Infection Control, Institute for Quantitative Biosciences, The University of Tokyo, Tokyo, Japan.
Takuya KatayamaDepartment of Biotechnology, The University of Tokyo, Tokyo, Japan.
Takuya MiyakawaDepartment of Applied Biological Chemistry, The University of Tokyo, Tokyo, Japan.
Masaru TanokuraDepartment of Applied Biological Chemistry, The University of Tokyo, Tokyo, Japan.
Yasunori ChibaBiotechnology Research Institute for Drug Discovery, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki Japan.
Reiko ShinkuraLaboratory of Immunology and Infection Control, Institute for Quantitative Biosciences, The University of Tokyo, Tokyo, Japan.
Jun-Ichi MaruyamaDepartment of Biotechnology, The University of Tokyo, Tokyo, Japan.ORCID 0000-0002-5318-5366
The University of Tokyo · JPJapan Agency for Medical Research and Development · JPNational Institute of Advanced Industrial Science and Technology · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMonoclonal antibodies (mAbs) as biopharmaceuticals take a pivotal role in the current therapeutic applications. Generally mammalian cell lines, such as those derived from Chinese hamster ovaries (CHO), are used to produce the recombinant antibody. However, there are still concerns about the high cost and the risk of pathogenic contamination when using mammalian cells.

resultsAdalimumab was expressed in

conclusionThese results demonstrated an alternative low-cost platform for human antibody production by using

Indexed as

AntibodyAspergillus oryzaeFc receptorNeutralizationN-linked glycan

Identifiers

PMID32514366
PMCPMC7257131
OpenAlexW3032232792

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.