TrialCardiovascular diabetology2020

Metformin may adversely affect orthostatic blood pressure recovery in patients with type 2 diabetes: substudy from the placebo-controlled Copenhagen Insulin and Metformin Therapy (CIMT) trial.

What the trial testedrandomised · 412 people · 2020

Randomised comparison

+3.40mmHg+0.60 to +6.20

As reported

difference 3.4 mmHg, 95% CI 0.60–6.20

Randomised comparison

+1.30mmHg+0.30 to +2.60

As reported

difference 1.3 mmHg, 95% CI 0.30–2.60

the abstract, start to end

… blood pressure drop increased by 3.4 mmHg (95% CI 0.6; 6.2, p = 0.02) and diastolic blood pressure drop increased by 1.3 mmHg (95% CI 0.3; 2.6, …

← favours treatmentfavours comparator →

could be chance

Blood pressure

3.40.60–6.20

Blood pressure

1.30.30–2.60

MetforminBlood pressure

Metformin × blood pressurehelps?mixed

unlikelylikely

0.400.50 without it

← favours treatmentfavours comparator →

this papermore certainless certain

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