ReviewInternational journal of endocrinology and metabolism2020
Potential Adverse Effects of Female and Male Obesity on Fertility: A Narrative Review.
Review in International journal of endocrinology and metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07242534 (Effect of Semaglutide on Embryo Quality in Overweight and Obese Patients Undergoing In Vitro Fertilization. A Randomized Controlled Trial), which is not on this map. Cited by 38 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Semaglutide on Embryo Quality in Overweight and Obese Patients Undergoing In Vitro Fertilization. A Randomized Controlled Trial
Who cites it
38 citing papers in PubMed, 81 citations in OpenAlex.
- Investigating the Association Between Serum 25-Hydroxyvitamin D (25(OH)D) and Body Mass Index (BMI) With In Vitro Fertilization (IVF) Outcomes Among Iranian Women: A Case-Control Study.Health science reports · 2026Article
- Prevalence of Infertility, Associated Factors, and Treatment Seeking Among Reproductive Age Couples in Merhabete Woreda, Northshewa Ethiopia, 2023: A Cross-Sectional Study.Health science reports · 2026Article
- Radiomics analysis of early pregnancy ultrasound images to predict viability at the end of first trimester.Scientific reports · 2026Article
- Exploring the knowledge, attitudes, and perceptions of young men towards fertility in the UK: A cross-sectional survey.PloS one · 2026Article
- The high-risk factors of urinary infectious stones: a retrospective study.Translational andrology and urology · 2025Article
- Trends and disparities in mortality due to hypertensive disease and coexisting obesity in the USA: 1999-2023.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2025Article
- Prenatal exposure to environmentally relevant low-dosage dibutyl phthalate reduces placental efficiency in CD-1 mice.Toxicological sciences : an official journal of the Society of Toxicology · 2025Article
- Pathophysiological insights into asprosin: an emerging adipokine in reproductive health.Reviews in endocrine & metabolic disorders · 2025Review
- Immune Microenvironment Dysregulation: A Contributing Factor to Obesity-Associated Male Infertility.Biomedicines · 2025Review
- Maternal cafeteria diet adversely affects the reproductive parameters of rat offspring in a sex-specific manner.Reproductive biology and endocrinology : RB&E · 2025Article
- The relevance of female overweight in infertility treatment: a position statement of the Italian Society of Fertility and Sterility and Reproductive Medicine (SIFES-MR).Journal of assisted reproduction and genetics · 2025Article
- Effects of pre-pregnancy BMI and gestational weight gain on pregnancy and neonatal outcomes in Poland.Scientific reports · 2025Article
- Medical therapy to treat obesity and optimize fertility in women of reproductive age: a narrative review.Reproductive biology and endocrinology : RB&E · 2025Review
- Correlation between uterine microbiota and pregnancy outcomes of embryo transfer in overweight and obese women.Frontiers in cellular and infection microbiology · 2025Article
- Review
- Impact of bariatric surgery on infertility in obese women: a systematic review and meta-analysis.Annals of medicine and surgery (2012) · 2024Article
- Efficacy of intrauterine autologous blood cell derivatives in enhancing endometrial thickness and IVF outcomes for women with recurrent implantation failure: a retrospective cohort study.Journal of assisted reproduction and genetics · 2024Article
- Preconception and Early-Pregnancy Body Mass Index in Women and Men, Time to Pregnancy, and Risk of Miscarriage.JAMA network open · 2024Article
- Male Infertility: New Developments, Current Challenges, and Future Directions.The world journal of men's health · 2024Review
- Pregnancy following assisted reproductive technology in morbidly obese patients: assessment of feto-maternal outcomes.Journal of assisted reproduction and genetics · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextDespite several studies documenting that obesity affects female and male fertility and leads to multiple adverse reproductive outcomes, the mechanisms involved are not elucidated. We aimed to summarize the potential adverse effects of female and male obesity, as well as the impact of weight loss on their fertility status. EVIDENCE ACQUISITION: This review summarizes papers investigating the potential adverse effects of female and male obesity and the impact of weight-loss interventions on fertility among reproductive age populations. PubMed, Scopus, Web of Science, and Google Scholar databases were searched for retrieving studies published up to November 2019 on obesity/overweight among reproductive age populations.
resultsThe review of 68 studies revealed that female and male obesity/overweight increases the risk of sub-fecundity and infertility. The destructive effects of female obesity on reproduction are attributed to a variety of ovarian and extra-ovarian factors. In women with overweight or obesity, the time taken to conceive is longer, and they have a decreased fertility rate, increased requirement for gonadotropins, and higher miscarriage rate when compared to those with normal weight. Male obesity may lead to subfertility, mainly because of the disruption of the hypothalamus-pituitary-gonadal (HPG) axis, increased testicular temperature, impairment of the physical and molecular structure of sperm, decreased sperm quality, and erectile dysfunction due to peripheral vascular disease. Most studies recommend lifestyle interventions as first-line therapy in the general population of women and men with obesity and infertility.
conclusionsThis study shows the negative effects of female and male overweight and obesity on fertility. Therefore, educational interventions on the adverse effects of obesity and the benefits of weight reduction, such as increasing pregnancy rate, should be considered for couples seeking fertility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.