ReviewMolecules (Basel, Switzerland)2021
Smell and Stress Response in the Brain: Review of the Connection between Chemistry and Neuropharmacology.
Review in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- How to Tackle Mental Fatigue: A Systematic Review of Potential Countermeasures and Their Underlying Mechanisms.Sports medicine (Auckland, N.Z.) · 2022Pooled it
- The effect of aromatherapy and music therapy on blood pressure and heart rate of nursing students before taking the exam.Scientific reports · 2025Trial
- Terpenes as Potential Multi-Target Modulators of Chronic Stress-Induced Neuroendocrine-Immune Dysregulation.International journal of molecular sciences · 2026Review
- Article
- An experimental study of the acute effects of visual and olfactory nature stimuli on task performance.Frontiers in psychology · 2026Article
- Effect of Phenolic Compounds and Terpenes on the Flavour and Functionality of Plant-Based Foods.Nutrients · 2025Review
- A randomized controlled trial effect of forest hiking on tensor muscle function, erythrocyte factors, and leukocytes' subsets in older adults: a pilot study.Journal of exercise rehabilitation · 2025Article
- A Comprehensive Review on Anxiolytic Effect ofFood science & nutrition · 2025Review
- Benefits of Gardenia jasminoides Ellis's floral volatile components on human emotions and moods.Scientific reports · 2025Article
- Antiparasitic Activities of Acyl Hydrazones from Cinnamaldehydes and Structurally Related Fragrances.Antibiotics (Basel, Switzerland) · 2024Article
- Antidepressant Effect and Mechanism ofJournal of microbiology and biotechnology · 2024Article
- Social odor choice buffers drug craving.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Lavender Essential Oil Inhalation Improves Attentional Shifting and Accuracy: Evidence from Dynamic Changes of Cognitive Flexibility and Power Spectral Density of Electroencephalogram Signals.Journal of medical signals and sensors · 2024Article
- Deep rest: An integrative model of how contemplative practices combat stress and enhance the body's restorative capacity.Psychological review · 2024Article
- Assessing the Anxiolytic and Relaxation Effects ofFrontiers in psychology · 2024Article
- Worms love Coffee too! Characterizing the neural substrates that regulate odor-guided responses to coffee.microPublication biology · 2024Article
- Olfactory stimulation with multiple odorants prevents stress-induced cognitive and psychological alterations.Brain communications · 2024Article
- Folate and Cobalamin Deficiencies during Pregnancy Disrupt the Glucocorticoid Response in Hypothalamus throughInternational journal of molecular sciences · 2023Article
- Social Odour Perception and Stress Responses in Women's Quality of Partner Relationship and Attachment Style.Behavioral sciences (Basel, Switzerland) · 2023Article
- Biomarkers in the Rat Hippocampus and Peripheral Blood for an Early Stage of Mental Disorders Induced by Water Immersion Stress.International journal of molecular sciences · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The stress response in the brain is not fully understood, although stress is one of the risk factors for developing mental disorders. On the other hand, the stimulation of the olfactory system can influence stress levels, and a certain smell has been empirically known to have a stress-suppressing effect, indeed. In this review, we first outline what stress is and previous studies on stress-responsive biomarkers (stress markers) in the brain. Subsequently, we confirm the olfactory system and review previous studies on the relationship between smell and stress response by species, such as humans, rats, and mice. Numerous studies demonstrated the stress-suppressing effects of aroma. There are also investigations showing the effects of odor that induce stress in experimental animals. In addition, we introduce recent studies on the effects of aroma of coffee beans and essential oils, such as lavender, cypress, α-pinene, and thyme linalool on the behavior and the expression of stress marker candidates in the brain. The transfer of volatile components into the brain is also discussed while using the results of thyme linalool as an example. These studies may provide a good opportunity to connect chemical research at the molecular level with neuropharmacological approaches in the future.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.