Evidence map›Paper›PMID 34483907›Full record

ReviewFrontiers in pharmacology2021

Therapeutic Applications of Terpenes on Inflammatory Diseases.

María Luisa Del Prado-Audelo, Hernán Cortés, Isaac H Caballero-Florán, Maykel González-Torres, Lidia Escutia-Guadarrama, Sergio A Bernal-Chávez, David M Giraldo-Gomez, Jonathan J Magaña, Gerardo Leyva-Gómez

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers.

0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed
15.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

86 citing papers in PubMed, 171 citations in OpenAlex.

  1. Article
  2. Review
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  9. Herbicidal Activity of the Invasive WeedPlants (Basel, Switzerland) · 2026
    Article
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  11. Review
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  20. Article

26 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

María Luisa Del Prado-AudeloEscuela de Ingeniería y Ciencias, Departamento de Bioingeniería, Instituto Tecnologico de Monterrey, Ciudad de México, México.
Hernán CortésLaboratorio de Medicina Genómica, Departamento de Genómica, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Ciudad de México, México.
Isaac H Caballero-FloránDepartamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, México.
Maykel González-TorresCONACyT-Laboratorio de Biotecnología, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Ciudad de México, México.
Lidia Escutia-GuadarramaDepartamento de Física, Facultad de Ciencias, Universidad Nacional Autónoma de México, Ciudad de México, México.
Sergio A Bernal-ChávezDepartamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, México.
David M Giraldo-GomezDepartamento de Biología Celular y Tisular, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Ciudad de México, México.
Jonathan J MagañaEscuela de Ingeniería y Ciencias, Departamento de Bioingeniería, Instituto Tecnologico de Monterrey, Ciudad de México, México.
Gerardo Leyva-GómezDepartamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, México.
Universidad Nacional Autónoma de México · MXInstituto Nacional de Rehabilitación · MXTecnológico de Monterrey · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the last decades, the search for natural products with biological applications as alternative treatments for several inflammatory diseases has increased. In this respect, terpenes are a family of organic compounds obtained mainly from plants and trees, such as tea, cannabis, thyme, and citrus fruits like lemon or mandarin. These molecules present attractive biological properties such as analgesic and anticonvulsant activities. Furthermore, several studies have demonstrated that certain terpenes could reduce inflammation symptoms by decreasing the release of pro-inflammatory cytokines for example, the nuclear transcription factor-kappa B, interleukin 1, and the tumor necrosis factor-alpha. Thus, due to various anti-inflammatory drugs provoking side effects, the search and analysis of novel therapeutics treatments are attractive. In this review, the analysis of terpenes' chemical structure and their mechanisms in anti-inflammatory functions are addressed. Additionally, we present a general analysis of recent investigations about their applications as an alternative treatment for inflammatory diseases. Furthermore, we focus on terpenes-based nanoformulations and employed dosages to offer a global perspective of the state-of-the-art.

Indexed as

anti-inflammatoryformulationsnatural productsterpenesterpenoids

Identifiers

PMID34483907
PMCPMC8414653
OpenAlexW3193476873

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.