Evidence map›Paper›PMID 35277067›Full record

Trial reportNutrients2022

Differential Glycemic Effects of Low- versus High-Glycemic Index Mediterranean-Style Eating Patterns in Adults at Risk for Type 2 Diabetes: The MEDGI-Carb Randomized Controlled Trial.

Robert E Bergia, Rosalba Giacco, Therese Hjorth, Izabela Biskup, Wenbin Zhu, Giuseppina Costabile, Marilena Vitale, Wayne W Campbell, Rikard Landberg, Gabriele Riccardi

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Nutritional benefits of sourdoughs: A systematic review.Advances in nutrition (Bethesda, Md.) · 2023
    Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Trial
  6. Trial
  7. Trial
  8. Trial
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Robert E BergiaDepartment of Nutrition Science, Purdue University, 700 West State St., West Lafayette, IN 47907, USA.ORCID 0000-0002-7980-8541
Rosalba GiaccoDiabetes, Nutrition and Metabolism Unit, Department of Clinical Medicine and Surgery, Federico II University, 80138 Naples, Italy.ORCID 0000-0002-4006-9761
Therese HjorthDepartment of Biology and Biological Engineering, Food Science and Nutrition, Chalmers University of Technology, 41296 Gothenburg, Sweden.
Izabela BiskupDepartment of Biology and Biological Engineering, Food Science and Nutrition, Chalmers University of Technology, 41296 Gothenburg, Sweden.
Wenbin ZhuDepartment of Statistics, Purdue University, West Lafayette, IN 47907, USA.ORCID 0000-0002-0980-3593
Giuseppina CostabileDiabetes, Nutrition and Metabolism Unit, Department of Clinical Medicine and Surgery, Federico II University, 80138 Naples, Italy.ORCID 0000-0001-5761-8002
Marilena VitaleDiabetes, Nutrition and Metabolism Unit, Department of Clinical Medicine and Surgery, Federico II University, 80138 Naples, Italy.ORCID 0000-0001-9951-4674
Wayne W CampbellDepartment of Nutrition Science, Purdue University, 700 West State St., West Lafayette, IN 47907, USA.
Rikard LandbergDepartment of Biology and Biological Engineering, Food Science and Nutrition, Chalmers University of Technology, 41296 Gothenburg, Sweden.
Gabriele RiccardiDiabetes, Nutrition and Metabolism Unit, Department of Clinical Medicine and Surgery, Federico II University, 80138 Naples, Italy.ORCID 0000-0003-4151-8298

Funding

Barilla (Italy) N/A
6 · The paper itself

Abstract

A Mediterranean-style healthy eating pattern (MED-HEP) supports metabolic health, but the utility of including low-glycemic index (GI) foods to minimize postprandial glucose excursions remain unclear. Therefore, we investigated the relative contribution of GI towards improvements in postprandial glycemia and glycemic variability after adopting a MED-HEP. We conducted a randomized, controlled dietary intervention, comparing high- versus low-GI diets in a multi-national (Italy, Sweden, and the United States) sample of adults at risk for type 2 diabetes. For 12 weeks, participants consumed either a low-GI or high-GI MED-HEP. We assessed postprandial plasma glucose and insulin responses to high- or low-GI meals, and daily glycemic variability via continuous glucose monitoring at baseline and post-intervention. One hundred sixty adults (86 females, 74 males; aged 55 ± 11 y, BMI 31 ± 3 kg/m2, mean ± SD) with ≥two metabolic syndrome traits completed the intervention. Postprandial insulin concentrations were greater after the high-GI versus the low-GI test meals at baseline (p = 0.004), but not post-intervention (p = 0.17). Postprandial glucose after the high-GI test meal increased post-intervention, being significantly higher than that after the low-GI test meal (35%, p < 0.001). Average daily glucose concentrations decreased in both groups post-intervention. Indices of 24-h glycemic variability were reduced in the low-GI group as compared to baseline and the high-GI intervention group. These findings suggest that low-GI foods may be an important feature within a MED-HEP.

Indexed as

Diabetes Mellitus, Type 2Glycemic IndexAdultAgedBlood GlucoseBlood Glucose Self-MonitoringFemaleHumansMaleMiddle AgedPostprandial PeriodBlood Glucosecontinuous glucose monitoringglycemic variabilityimpaired glycemic controlinsulinemiameal glucose tolerance testMediterranean dietmetabolic healthmetabolic risk factorsmetabolic syndromeoral glucose tolerance test

Identifiers

PMID35277067
PMCPMC8838655

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.