Trial reportEuropean journal of clinical nutrition2022
The effect of multistrain probiotics on functional constipation in the elderly: a randomized controlled trial.
Trial report in European journal of clinical nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06619067 (Efficacy Study of the Probiotic Food Supplement PROBAFLOR for Maintaining Intestinal Well-being), which is not on this map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy Study of the Probiotic Food Supplement PROBAFLOR for Maintaining Intestinal Well-being: Single-centre, Controlled, Randomized, Parallel Group, Double-blind Clinical Study
Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- Systematic Review and Meta-Analysis of Tuina as an Adjuvant Therapy for Functional Constipation in Children.Healthcare (Basel, Switzerland) · 2026Review
- Smart CaCOScientific reports · 2026Article
- Effects of Lacticaseibacillus rhamnosus MP108 on functional constipation symptoms and gut microbiota in children.Pediatric research · 2026Article
- Research progress and controversies in the treatment of functional constipation-related depression with probiotics and prebiotics: a narrative review.Frontiers in pharmacology · 2026Review
- Fermentation of Fruits and Vegetables: Bridging Traditional Wisdom and Modern Science for Food Preservation and Nutritional Value Improvements.Foods (Basel, Switzerland) · 2025Review
- Recent advances in therapeutic probiotics: insights from human trials.Clinical microbiology reviews · 2025Review
- Probiotics and prebiotics in the treatment of functional constipation in the elderly individuals.World journal of gastrointestinal pharmacology and therapeutics · 2025Review
- Article
- Evaluation of Four Multispecies Probiotic Cocktails in a Human Colonic Fermentation Model.Probiotics and antimicrobial proteins · 2024Article
- Randomised, Placebo-Controlled Investigation of the Impact of Probiotic Consumption on Gut Microbiota Diversity and the Faecal Metabolome in Seniors.Microorganisms · 2024Article
- Prebiotics and Probiotics for Gastrointestinal Disorders.Nutrients · 2024Review
- A Mini Literature Review of Probiotics: Transforming Gastrointestinal Health Through Evidence-Based Insights.Cureus · 2024Review
- Constipation among Korean older adults in long-term care facilities: A scoping review.Journal of Korean gerontological nursing · 2024Review
- Effectiveness of Probiotics in Patients With Constipation: A Systematic Review and Meta-Analysis.Cureus · 2024Review
- Supplementation with probiotics, prebiotics, and synbiotics in patients with chronic functional constipation: a randomized, double-blind, placebo-controlled pilot clinical trial.Gastroenterology report · 2024Article
- Fermented Vegetables: Health Benefits, Defects, and Current Technological Solutions.Foods (Basel, Switzerland) · 2023Review
- Revisiting the Intestinal Microbiome and Its Role in Diarrhea and Constipation.Microorganisms · 2023Review
- Review
- Stimulatory Effect of Lactobacillus Metabolites on Colonic Contractions in Newborn Rats.International journal of molecular sciences · 2022Article
- Association between Depression, Anxiety Symptoms and Gut Microbiota in Chinese Elderly with Functional Constipation.Nutrients · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesConstipation is one of the most common gastrointestinal conditions, particularly among older individuals. This study aimed to evaluate the efficacy and safety of selected multistrain probiotics on functional constipation and laboratory blood parameters in the elderly living in a nursing home. SUBJECTS AND
methodsSixty participants (42 females and 18 males) aged 77.9 ± 8.84 years with functional constipation, who met the eligibility criteria, completed the study. In a double-blind, placebo-controlled, parallel design, each participant was randomized to receive either the selected probiotic mixture (N = 28) or placebo (N = 32) for 12 weeks as an adjunct to their usual diet and medications. The liquid probiotic formulation containing Bifidobacterium animalis subsp. lactis BLC1, Lactobacillus acidophilus LA3 and Lactobacillus casei BGP93 was tested for the first time.
resultsSupplementation of selected probiotics resulted in a slight but nonsignificant increase in cumulative stool frequency compared with placebo. However, after the 71st day of the treatment, the cumulative number of stools was significantly higher in the probiotic group (P < 0.05) when the influence of laxative was excluded. The trend towards an increase in the difference between the two groups, which began 1 week after the probiotic intervention, pointed out to their prolonged effect. There were no significant dependent or independent effects of treatment and time on most of the 27 laboratory blood parameters tested.
conclusionsMultistrain probiotic supplementation was found to be efficacious, safe and well tolerated in the elderly with functional constipation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.