Evidence map›Paper›PMID 36542005›Full record

SynthesisArquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery2022

THE INTESTINAL MICROBIOME IN PATIENTS UNDERGOING BARIATRIC SURGERY: A SYSTEMATIC REVIEW.

João Kleber Almeida Gentile, Karen Danielle Oliveira, Júlia Guimarães Pereira, Daniel Yuji Tanaka, Giovanna Nagatsuka Guidini, Melissa Zanetti Cadona, Diego Werneck Siriani-Ribeiro, Mariana Tafner Perondini

Registry-linked trialOpen access · diamondAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06132477 (Biometabolic Impact of Continuation of GLP-1 Agonists Following Bariatric), which is not on this map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06132477 phase4recruitingstarted 2024, after this paper: background citation

Biometabolic Impact of Continuation of GLP-1 Agonists Following Bariatric

Ran2024Enrolled150Registered outcomes5Posted comparisons0ConditionsDiabetes Mellitus, Hypertension, Metabolic Syndrome, Morbid ObesityArmsGLP-1 receptor agonist
PMID 28266779PMID 36765019PMID 32656729PMID 21844879PMID 29551470PMID 29730732PMID 30315341PMID 31502183PMID 31666597PMID 32163341PMID 32198618PMID 32785814other papers from this trial
Open the trial in the graph
3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Gut Microbiota and Metabolic Health: From Dysbiosis to Therapeutics.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2026
    Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. VITAMIN D LEVELS AND LIPID PROFILE IN PATIENTS UNDERGOING BARIATRIC SURGERY.Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

João Kleber Almeida GentileFaculty of Medicine, City of São Paulo University, Surgical Skills and Operative Technique Unit - São Paulo (SP), Brazil.ORCID http://orcid.org/0000-0001-8650-2703
Karen Danielle OliveiraSão Camilo Hospital, Pompéia Unit, Clinical Nutrition Department, São Paulo (SP), Brazil.ORCID http://orcid.org/0000-0002-4956-9826
Júlia Guimarães PereiraFaculty of Medicine, City of São Paulo University, São Paulo (SP), Brazil.ORCID http://orcid.org/0000-0001-8122-1574
Daniel Yuji TanakaFaculty of Medicine, City of São Paulo University, São Paulo (SP), Brazil.ORCID http://orcid.org/0000-0002-8599-7668
Giovanna Nagatsuka GuidiniFaculty of Medicine, City of São Paulo University, São Paulo (SP), Brazil.ORCID http://orcid.org/0000-0002-7613-1176
Melissa Zanetti CadonaFaculty of Medicine, City of São Paulo University, São Paulo (SP), Brazil.ORCID http://orcid.org/0000-0002-1011-8956
Diego Werneck Siriani-RibeiroFaculty of Medicine, City of São Paulo University, São Paulo (SP), Brazil.ORCID http://orcid.org/0000-0001-7215-9625
Mariana Tafner PerondiniFaculty of Medicine, City of São Paulo University, São Paulo (SP), Brazil.ORCID http://orcid.org/0000-0002-4276-0257
Universidade de São Paulo · BRSão Camilo Hospital · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDysbiosis of the gut microbiota is frequently found in cases of obesity and related metabolic diseases, such as type 2 diabetes mellitus. The composition of the microbiota in diabetics is similar to that of obese people, thereby causing increased energy uptake efficiency in the large intestine of obese people, maintenance of a systemic inflammatory state, and increased insulin resistance. Bariatric surgery seems to entail an improvement in gut dysbiosis, leading to an increased diversity of the gut microbiota.

aimsThis study aimed to present a literature review on obesity-associated gut dysbiosis and its status post-bariatric surgery.

methodsA systematic review of primary studies was conducted in PubMed, SciELO, BIREME, LILACS, Embase, ScienceDirect, and Scopus databases using DeCS (Health Science Descriptors) with the terms "obesity," "intestinal dysbiosis," "bariatric surgery," and "microbiota."

resultsWe analyzed 28 articles that had clinical studies or literature reviews as their main characteristics, of which 82% (n=23) corresponded to retrospective studies. The sample size of the studies ranged from 9 to 257 participants and/or fecal samples. The epidemiological profile showed a higher prevalence of obesity in females, ranging from 24.4 to 35.1%, with a mean age of around 25-40 years. There was a variation regarding the type of bariatric surgery, migrating between the Roux-en-Y bypass, adjustable gastric banding, and vertical gastrectomy. Of the 28 studies, 6 of them evaluated the gut microbiota of obese patients undergoing bariatric surgery and their relationship with type 2 diabetes mellitus/glucose metabolism/insulin resistance.

conclusionsThe intestinal microbiota is an important influencer in the regulation of the digestive tract, and obese individuals with comorbidities (diabetes mellitus, hypercholesterolemia, and metabolic syndrome) present important alterations, with an unbalance normal state, generating dysbiosis and the proliferation of bacterial species that favor the appearance of new diseases. Patients who undergo bariatric surgery present an improvement in the intestinal microbiota imbalance as well as reversibility of their comorbidities, increasing their life expectancy.

Indexed as

Bariatric SurgeryDiabetes Mellitus, Type 2Gastric BypassGastrointestinal MicrobiomeInsulin ResistanceObesity, MorbidAdultDysbiosisFemaleHumansObesityRetrospective Studies

Identifiers

PMID36542005
PMCPMC9767418
OpenAlexW4312113144

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.