Antihypertensives × blood pressure

SynthesisThe Cochrane database of systematic reviews2023

Pharmacological interventions for asymptomatic carotid stenosis.

Caroline Nb Clezar et al.PubMed ↗Full text ↗Publisher ↗

What the trial testedas reported · 11,571 people · 2023

Range includes no effect

No clear effect on adverse events & safety

0.1× to 16×

Bigger than 1 in 10 for adverse events & safety

As reported

RR 0.98, 95% CI 0.06–15.5

Range includes no effect

No clear effect on blood pressure

−86%−98% to +16%

Bigger than almost all on the map

As reported

RR 0.14, 95% CI 0.02–1.16

Range includes no effect

No clear effect on blood pressure

−43%−83% to +94%

Bigger than 8 in 10 on the map

As reported

RR 0.57, 95% CI 0.17–1.94

Range includes no effect

No clear effect on cardiovascular events

−64%−91% to +53%

Bigger than almost all for cardiovascular events

As reported

RR 0.36, 95% CI 0.09–1.53

+2 more in the walkthrough ↓

Six numbers in the abstract

the abstract, start to end

on major bleeding is very uncertain (RR 0.98, 95% CI 0.06 to 15.53; very

major or disabling stroke (RR 0.14, 95% CI 0.02 to1.16; 1 study, 793 participants) and stroke-related mortality (RR 0.57, 95% CI 0.17 to 1.94; 1 study,

pravastatin, and rosuvastatin; RR 0.36, 95% CI 0.09 to 1.53; 5 studies, 2235 participants) stroke-related mortality (lovastatin and pravastatin; RR 0.25, 95% CI 0.03 to 2.29; 2 studies, 1366 participants), and adverse events (fluvastatin, lovastatin, pravastatin, probucol, and rosuvastatin; RR 0.76, 95% CI 0.53 to1.10; 7 studies,

← favours treatmentfavours comparator →
could be chance
Adverse events & safety
RR 0.980.06–15.5
Blood pressure
RR 0.140.02–1.16
Blood pressure
RR 0.570.17–1.94
Cardiovascular events
RR 0.360.09–1.53
Cardiovascular events
RR 0.250.03–2.29
Adverse events & safety
RR 0.760.53–1.10
StatinsOther lipid agentsAntihypertensivesAntiplatelet & anticoagulantBlood pressureCardiovascular eventsAdverse events & safety

Antihypertensives × blood pressurehelps?replicated

unlikelylikely
0.96not counted

Other lipid agents × cardiovascular eventshelps?settled

unlikelylikely
0.80not counted

Statins × cardiovascular eventshelps?replicated

unlikelylikely
0.86not counted
← favours treatmentfavours comparator →
more certainless certain
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