Evidence map›Paper›PMID 38286487›Full record

SynthesisBMJ (Clinical research ed.)2024

Comparative effectiveness of GLP-1 receptor agonists on glycaemic control, body weight, and lipid profile for type 2 diabetes: systematic review and network meta-analysis.

Haiqiang Yao, Anqi Zhang, Delong Li, Yuqi Wu, Chong-Zhi Wang, Jin-Yi Wan, Chun-Su Yuan

Registry-linked trialOpen access · hybridAbstract readSystematic ReviewNetwork Meta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMJ (Clinical research ed.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07100691 (Preoperative Metoclopramide to Enhance Gastric Emptying in Patients on Glucagon-Like Peptide-1 Receptor Agonists for Weight Loss), which is not on this map. Cited by 297 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
297citing papers in PubMed, 15 pooled it
151.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07100691 phase4not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Preoperative Metoclopramide to Enhance Gastric Emptying in Patients on Glucagon-Like Peptide-1 Receptor Agonists for Weight Loss: A Randomised Controlled Trial With Ultrasound Assessment

TypeinterventionalSponsorMater Misericordiae University HospitalRan2025 to 2026Enrolled80ConditionsPulmonary Aspiration During Anaesthetic Induction, Gastric Emptying Time, Preoperative Risk Assessment, Obesity (Disorder)ArmsMetoclopramide
3 · Its place in the literature

Who cites it

297 citing papers in PubMed, 15 syntheses or guidelines pooled it, 424 citations in OpenAlex.

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237 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Haiqiang YaoSchool of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.
Anqi ZhangNational Institute of TCM Constitution and Preventive Medicine, Beijing University of Chinese Medicine, Beijing, China.
Delong LiSchool of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.
Yuqi WuSchool of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.
Chong-Zhi WangTang Center for Herbal Medicine Research, University of Chicago, Chicago, IL, USA.
Jin-Yi WanSchool of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.ORCID 0000-0001-8830-2035
Chun-Su YuanTang Center for Herbal Medicine Research, University of Chicago, Chicago, IL, USA.
Beijing University of Chinese Medicine · CNUniversity of Chicago · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the comparative efficacy and safety of glucagon-like peptide-1 receptor agonists (GLP-1RAs) on glycaemic control, body weight, and lipid profile in adults with type 2 diabetes.

designSystematic review and network meta-analysis. DATA SOURCES: PubMed, Web of Science, Cochrane Central Register of Controlled Trials (CENTRAL), and Embase from database inception to 19 August 2023. ELIGIBILITY CRITERIA FOR SELECTING STUDIES: Eligible randomised controlled trials enrolled adults with type 2 diabetes who received GLP-1RA treatments and compared effects with placebo or any GLP-1RA drug, with a follow-up duration of at least 12 weeks. Trials with a crossover design, non-inferiority studies comparing GLP-1RA and other drug classes without a placebo group, using withdrawn drugs, and non-English studies were deemed ineligible.

results76 eligible trials involving 15 GLP-1RA drugs and 39 246 participants were included in this network meta-analysis; all subsequent estimates refer to the comparison with placebo. All 15 GLP-1RAs effectively lowered haemoglobin A

conclusionsGLP-1RAs are efficacious in treating adults with type 2 diabetes. Compared with the placebo, tirzepatide was the most effective GLP-1RA drug for glycaemic control by reducing haemoglobin A SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42022342845.

Indexed as

Diabetes Mellitus, Type 2AdultBlood GlucoseBody WeightGlucagon-Like Peptide-1 Receptor AgonistsGlycated HemoglobinGlycemic ControlHumansHypoglycemic AgentsLipid MetabolismWeight LossBlood GlucoseGlucagon-Like Peptide-1 Receptor AgonistsGlycated HemoglobinHypoglycemic Agents

Identifiers

PMID38286487
PMCPMC10823535
OpenAlexW4391309422

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.