Evidence map›Paper›PMID 38888262›Full record

ArticleANZ journal of surgery

The impact of obesity on postoperative outcomes following surgery for colorectal cancer: analysis of the National Inpatient Sample 2015-2019.

Tania Kazi, Tyler McKechnie, Yung Lee, Rehab Alsayari, Gaurav Talwar, Aristithes Doumouras, Dennis Hong, Cagla Eskicioglu

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in ANZ journal of surgery. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It reports registered trial NCT07314528. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07314528 phase2not yet recruiting

A Phase II Multi-institutional Randomized Trial Evaluating the Impact of GLP-1 Receptor Agonists in Combination With Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer

Ran2026Enrolled42Registered outcomes23Posted comparisons0ConditionsGLP-1, Locally Advanced Rectal Cancer (LARC), Obesity &Amp; Overweight, Rectal Cancer PatientsArmsGLP-1 receptor agonist, Total neoadjuvant therapy (TNT)
PMID 33567185PMID 36294412PMID 40437949PMID 40285503PMID 40140925PMID 39093546PMID 38967919PMID 38893212PMID 37085291PMID 35565381PMID 32923389other papers from this trial
Open the trial in the graph
3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Metabolic Modulation in Cancer Care: The Potential Role of Glucagon-Like Peptide-1 Receptor Agonists.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tania KaziMichael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada.ORCID 0009-0004-2360-2159
Tyler McKechnieDivision of General Surgery, Department of Surgery, McMaster University, Hamilton, Ontario, Canada.
Yung LeeDivision of General Surgery, Department of Surgery, McMaster University, Hamilton, Ontario, Canada.
Rehab AlsayariDivision of General Surgery, Department of Surgery, McMaster University, Hamilton, Ontario, Canada.
Gaurav TalwarDivision of General Surgery, Department of Surgery, McMaster University, Hamilton, Ontario, Canada.ORCID 0000-0002-7691-4314
Aristithes DoumourasMichael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada.
Dennis HongMichael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada.
Cagla EskiciogluMichael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada.ORCID 0000-0003-3920-066X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe global burden of obesity has reached epidemic proportions, placing great strain on the North American healthcare system. We designed a retrospective cohort database study comparing postoperative morbidity and healthcare resource utilization between patients living with and without obesity undergoing surgery for colorectal cancer.

methodsAdult patients undergoing resection for colorectal cancer were identified from the 2015 to 2019 National Inpatient Sample database. Patients were stratified according to obesity status (i.e., body mass index of 30 kg/m

resultsAfter PSM, 7565 non-obese and 7565 obese patients were included. Patients with obesity had a 10% increase in relative risk of overall in-hospital postoperative morbidity (23.1% versus 25.6%, P = 0.0015) and a $4564 increase in hospitalization cost ($70 248 USD versus $74 812 USD, P = 0.0004). Patients with obesity were more likely to require post-operative ICU admission (5.0% versus 8.0%, P < 0.0001) and less likely to be discharged home after their index operation (68.3% versus 64.2%, P = 0.0022).

conclusionPatients with obesity undergoing surgery for colorectal cancer may be at an increased risk of in-hospital postoperative morbidity. They may also be more likely to have increased hospitalization costs, post-operative ICU admissions, and to not be discharged directly home. Preoperative optimization via weight loss strategies should be further explored.

Indexed as

Colorectal NeoplasmsObesityPostoperative ComplicationsAdultAgedDatabases, FactualFemaleHumansLength of StayMaleMiddle AgedPropensity ScoreRetrospective StudiesUnited Statescolorectal cancercolorectal neoplasiacolorectal surgeryobesitypostoperative morbidity

Identifiers

PMID38888262

What Socratic holds

Textmetadata
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.