Statins × adverse events & safety

SynthesisLipids in health and disease2024

Efficacy and safety of statin therapy in kidney transplant recipients: a systematic review and meta-analysis.

Ioannis Bellos et al.PubMed ↗Full text ↗Publisher ↗

  • Statin usecuts both waysLower major heart events, fewer overall deaths, lower hepatotoxicity.Correlation only, not a test of it.

What moved togetherboth groups pooled, not the treatment’s effect

Correlation, not cause

Statin use went with lower major heart events

−13%−33% to −4%

Statin use vs no use

Bigger than 2 in 10 for cardiovascular events

As reported

RR 0.87, 95% CI 0.67–0.96 · the paper's word: major adverse cardiovascular events

Correlation, not cause

Statin use went with fewer overall deaths

−16%−26% to −6%

Statin use vs no use

Bigger than 5 in 10 for all-cause mortality

As reported

RR 0.84, 95% CI 0.74–0.94 · the paper's word: overall mortality

Correlation, not cause

Statin use went with lower hepatotoxicity

−19%−30% to −7%

Statin use vs no use

Bigger than 5 in 10 for adverse events & safety

As reported

RR 0.81, 95% CI 0.70–0.93

+2 more in the walkthrough ↓

Who was studied, and how

people with cardiovascular disease, in this paper

Already taking Statin use, or nottheir own situation, not assigned

on Statin use
not on use

Statin use went with lower major heart events−13%

Statin use went with fewer overall deaths−16%

Statin use went with lower hepatotoxicity−19%

correlation, not a test

the abstract, start to end

events [Relative risk (RR): 0.87, 95% confidence interval (CI): 0.67-0.96, moderate certainty] and overall mortality (RR: 0.84, 95% CI: 0.74-0.94, low

with a lower risk of hepatotoxicity (RR: 0.81, 95% CI: 0.70-0.93, moderate certainty), but with a greater risk of rhabdomyolysis (RR: 1.37, 95% CI: 1.10-1.70, low certainty) and cataract (RR: 1.22, 95% CI: 1.14-1.31, moderate

← favours treatmentfavours comparator →
could be chance
Major adverse cardiovascular eventsStatin use vs no use
RR 0.870.67–0.96
Overall mortalityStatin use vs no use
RR 0.840.74–0.94
HepatotoxicityStatin use vs no use
RR 0.810.70–0.93
RhabdomyolysisStatin use vs no use
RR 1.371.10–1.70
CataractStatin use vs no use
RR 1.221.14–1.31
StatinsCardiovascular eventsAll-cause mortalityAdverse events & safety
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9 papers cite it

2024
2025
2026
this papercites it
Full record →Abstract, authors, funding and every citing paper · PMID 39261803