Statins × cardiovascular events

TrialHeart (British Cardiac Society)2025

Long-term benefits of atorvastatin on the incidence of cardiovascular events: the ASCOT-Legacy 20-year follow-up.

Peter S Sever et al.PubMed ↗Full text ↗Publisher ↗

  • Atorvastatinlooks good hereFewer non-fatal myocardial infarction and fatal coronary heart disease events, fewer total coronary events, fewer CV deaths.Randomised, small.

What the trial testedrandomised · 2025

Randomised vs placebo

Probably reduced non-fatal myocardial infarction and fatal coronary heart disease events

−19%−31% to −6%

atorvastatin vs placebo

Bigger than 4 in 10 for cardiovascular events

As reported

HR 0.81, 95% CI 0.69–0.94

Randomised vs placebo

Probably reduced total coronary events

−12%−20% to −2%

atorvastatin vs placebo

Bigger than 2 in 10 for cardiovascular events

As reported

HR 0.88, 95% CI 0.80–0.98

Randomised vs placebo

Probably reduced CV deaths

−14%−26% to −1%

atorvastatin vs placebo

Bigger than 3 in 10 for cardiovascular events

As reported

HR 0.86, 95% CI 0.74–0.99

Who was studied, and how

people with dyslipidemia, in this paper

The trial randomly assignedassigned by chance

atorvastatin
placebo

Probably reduced non-fatal myocardial infarction and fatal coronary heart disease events−19%

Probably reduced total coronary events−12%

Probably reduced CV deaths−14%

randomised

the abstract, start to end

heart disease (CHD) events (HR (95% CI) 0.81 (0.69 to 0.94, p=0.006)), total coronary events (0.88 (0.80 to 0.98, p=0.017)) and CV deaths (0.86 (0.74 to 0.99, p=0.048)).

← favours treatmentfavours comparator →
could be chance
Non-fatal myocardial infarction (MI) and fatal coronary heart disease (CHD) eventsatorvastatin vs placebo
HR 0.810.69–0.94
Total coronary eventsatorvastatin vs placebo
HR 0.880.80–0.98
CV deathsatorvastatin vs placebo
HR 0.860.74–0.99
StatinsCardiovascular events

Statins × cardiovascular eventshelps?replicated

unlikelylikely
0.860.85 without it
← favours treatmentfavours comparator →
this papermore certainless certain
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2 papers cite it

2025
2026
this paperpooled itcites it
Full record →Abstract, authors, funding and every citing paper · PMID 40139683