Other glucose-lowering × glycemic control

TrialDiabetes research and clinical practice2025

Baseline glucagon impacts glucose-lowering effects of acarbose but not metformin: A sub-analysis of MARCH study.

Lanxuan Jiang et al.PubMed ↗Publisher ↗

  • Acarboselooks good hereLower HbA1c reductions, no range given.No ranges given.

What the trial testedas reported · 493 people · 2025

No range given

Reported lower HbA1c reductions, no range given

−1.32percentage points

acarbose vs acarbose (low glucagon subgroup), in high baseline glucagon

As reported

difference −1.32 %, no interval

No range given

Reported lower HbA1c reductions, no range given

−1.27percentage points

acarbose vs acarbose (low glucagon subgroup), in medium baseline glucagon

As reported

difference −1.27 %, no interval

No range given

Reported lower HbA1c reductions, no range given

−1.23percentage points

acarbose vs acarbose (low glucagon subgroup), in high baseline glucagon

As reported

difference −1.23 %, no interval

No range given

Reported lower HbA1c reductions, no range given

−1.30percentage points

acarbose vs acarbose (low glucagon subgroup), in medium baseline glucagon

As reported

difference −1.30 %, no interval

Who was studied, and how

493people with type 2 diabetes, in this paper

Among high baseline glucagon, the trial randomly assignedassigned by chance

acarbose
acarbose (low glucagon subgroup)

Reported lower HbA1c reductions, no range given−1.32

randomised

Among medium baseline glucagon, the trial randomly assignedassigned by chance

acarbose
acarbose (low glucagon subgroup)

Reported lower HbA1c reductions, no range given−1.27

randomised

the abstract, start to end

greater HbA1c reductions at 24 weeks (-1.32 % for high and -1.27 % for medium vs. -0.87 % for low; both P < 0.05) and at 48 weeks (-1.23 % for high and -1.30 % for medium vs. -0.79 % for

← favours treatmentfavours comparator →
could be chance
No interval given · direction only, strength unknown
HbA1c reductionsacarbose vs acarbose (low glucagon subgroup), in high baseline glucagon
−1.32
HbA1c reductionsacarbose vs acarbose (low glucagon subgroup), in medium baseline glucagon
−1.27
HbA1c reductionsacarbose vs acarbose (low glucagon subgroup), in high baseline glucagon
−1.23
HbA1c reductionsacarbose vs acarbose (low glucagon subgroup), in medium baseline glucagon
−1.30
Other glucose-loweringGlycemic control
1 / 4

1 paper cites it

2025
2026
this papercites it
Full record →Abstract, authors, funding and every citing paper · PMID 40319921