Evidence map›Paper›PMID 40474187›Full record

Trial reportLipids in health and disease2025

Full-fat yogurt compared with non-fat yogurt reduces blood triacylglycerol concentrations and lowers the triacylglycerol content in specific lipoprotein subclasses in adults with prediabetes: an exploratory analysis of a randomized-controlled trial.

Victoria M Taormina, Simonne Eisenhardt, Matthew P Gilbert, Matthew E Poynter, C Lawrence Kien, Jana Kraft

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Lipids in health and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03577119 (Full-fat Yogurt and Glucose Tolerance), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03577119 nacompletednot on this map

Full-fat Yogurt and Glucose Tolerance

TypeinterventionalSponsorUniversity of Vermont Medical CenterRan2018 to 2022Enrolled13ConditionsPre-DiabetesArmsFull-fat yogurt, Non-fat yogurt
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Victoria M TaorminaDepartment of Animal and Veterinary Sciences, University of Vermont, Burlington, VT, USA.
Simonne EisenhardtDepartment of Animal and Veterinary Sciences, University of Vermont, Burlington, VT, USA.
Matthew P GilbertDepartment of Medicine, University of Vermont, Burlington, VT, USA.
Matthew E PoynterDepartment of Medicine, University of Vermont, Burlington, VT, USA.
C Lawrence KienDepartment of Medicine, University of Vermont, Burlington, VT, USA.
Jana KraftDepartment of Animal and Veterinary Sciences, University of Vermont, Burlington, VT, USA. Jana.Kraft@uvm.edu.

Funding

US Department of Agriculture National Institute of Food and Agriculture 2022-67011-36572
6 · The paper itself

Abstract

backgroundLow- and non-fat dairy foods have long been recommended over full-fat dairy foods due to the negative effect of saturated fatty acids on blood lipids. Recent research, however, suggests saturated fatty acids from dairy foods may not impart these negative health effects. Our objective was to evaluate changes in blood lipids following a diet with full-fat (3.25%) yogurt compared with a diet with non-fat yogurt.

methodsA randomized, double-masked crossover controlled-feeding trial was performed. Participants with prediabetes (n = 13, 7 female and 6 male participants) consumed three daily servings of full-fat or non-fat yogurt for the three weeks of each experimental diet. A one-week run-in diet preceded each experimental diet period. After each experimental diet period and the first run-in diet period, fasting blood and blood drawn at four post-prandial time points during a mixed meal tolerance test were analyzed for lipoprotein concentrations and contents (i.e., the lipid fractions within the lipoproteins). Statistical analyses were performed using linear mixed models, with values from the first run-in diet as the covariate.

resultsFasting blood triacylglycerol concentrations were 10% lower in response to the full-fat yogurt diet, compared with the non-fat yogurt diet (P < 0.01). While no diet-induced differences were observed in lipoprotein subclass concentrations, the triacylglycerol contents of smaller very low-density, intermediate-density, and low-density lipoproteins were lower in response to the full-fat yogurt diet (P ≤ 0.01). Trends indicated potentially greater high-density lipoprotein cholesterol concentrations and high-density lipoprotein size following the full-fat yogurt diet (P ≤ 0.05). The ratio of triacylglycerols: high-density lipoprotein cholesterol concentrations was 17% lower following the full-fat yogurt diet (P < 0.01).

conclusionsThis exploratory analysis demonstrates that short-term full-fat yogurt consumption elicits beneficial effects on the blood lipid profile in individuals with prediabetes and highlights the need for further evaluation of the contribution of dairy fat in yogurt and other dairy food matrices in lipid homeostasis and metabolic health.

trial registrationThis trial is registered at clinicaltrials.gov (NCT03577119).

Indexed as

Dietary FatsLipoproteinsPrediabetic StateTriglyceridesYogurtAdultCholesterol, HDLCross-Over StudiesDouble-Blind MethodFemaleHumansMaleMiddle AgedCholesterol, HDLDietary FatsLipoproteinsTriglyceridesBlood lipidsCardiometabolic healthCardiovascular disease riskControlled-feeding trialDairy fatDairy productsDietary fatLipoprotein compositionTriacylglycerol: high-density lipoprotein cholesterol ratioTriglycerides

Identifiers

PMID40474187
PMCPMC12139295

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.