ArticleNeuron2025
Locus coeruleus activation "resets" hippocampal event representations and separates adjacent memories.
Article in Neuron, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Cognitive reappraisal influences the organization of emotional episodes in memory.Cognitive, affective & behavioral neuroscience · 2026Article
- Article
- BOLD fMRI activations and LC contrast associated with successful episodic memory in healthy older adults and MCI.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Divergent modes of episodic organization underlie whether emotional learning enhances memory across event boundaries.Psychonomic bulletin & review · 2026Article
- Dopaminergic processes predict temporal distortions in event memory.Nature communications · 2026Article
- Semantic knowledge and hierarchical event structure can scaffold memory for temporal order.Journal of experimental psychology. Learning, memory, and cognition · 2026Article
- Sparsification and decorrelation of granule cell activity in the dentate gyrus by noradrenaline.Communications biology · 2026Article
- Spatial pattern separation deficits in early Alzheimer's disease are comparable in humans and animal models.Scientific reports · 2026Article
- Research progress on the role of the locus coeruleus in cognitive function.Frontiers in human neuroscience · 2026Review
- An experimental paradigm to manipulate physiological arousal using consecutive successes.iScience · 2025Article
- Strong mnemonic prediction errors increase cognitive control, attention, and arousal.bioRxiv : the preprint server for biology · 2025Article
- What can ANS signals tell us about motor learning? An implication for better assessment of cognitive contribution to motor learning.Frontiers in behavioral neuroscience · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Memories reflect the ebb and flow of experiences, capturing distinct events from our lives. Using a combination of functional magnetic resonance imaging (fMRI), neuromelanin imaging, and pupillometry, we show that arousal and locus coeruleus (LC) activation segment continuous experiences into discrete memories. As sequences unfold, encountering a context shift or event boundary triggers pupil-linked arousal and LC processes that predict later memory separation. Boundaries, furthermore, promote temporal pattern separation within the left hippocampal dentate gyrus, which correlates with heightened LC responses to those same transition points. Unlike transient LC effects, indirect structural and functional markers of elevated background LC activation correlate with reduced arousal-related LC and pupil responses at boundaries, suggesting that hyperarousal disrupts event segmentation. Our findings support the idea that arousal mechanisms initiate a neural and memory "reset" in response to significant changes, fundamentally shaping the episodes that define episodic memory.
Indexed as
Identifiers
40482639What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.