GIP/GLP-1 & amylin agonists × body weight & composition

TrialDiabetes, obesity & metabolism2025

Efficacy and safety of once-weekly tirzepatide in Japanese participants with type 2 diabetes who have obesity or overweight: Subpopulation analysis of the SURMOUNT-2 trial.

Toshimasa Yamauchi et al.PubMed ↗Full text ↗Publisher ↗

  • Tirzepatide 10 mglooks good hereLower percent change in body weight from baseline to week 72, no range given.No ranges given.
  • Tirzepatide 15 mglooks good hereLower percent change in body weight from baseline to week 72, no range given.No ranges given.

What the trial testedas reported · 2025

No range given

Reported lower percent change in body weight from baseline to week 72, no range given

−12.4percentage points

tirzepatide 10 mg vs placebo, in Japanese participants with obesity and type 2 diabetes (T2D) from SURMOUNT-2 trial

As reported

difference −12.4 %, no interval · the paper's word: mean percent change in body weight from baseline to week 72

No range given

Reported lower percent change in body weight from baseline to week 72, no range given

−10.2percentage points

tirzepatide 15 mg vs placebo, in Japanese participants with obesity and type 2 diabetes (T2D) from SURMOUNT-2 trial

As reported

difference −10.2 %, no interval · the paper's word: mean percent change in body weight from baseline to week 72

Who was studied, and how

people with obesity, in this paper

Among Japanese participants with obesity and type 2 diabetes (T2D) from SURMOUNT-2 trial, the trial randomly assignedassigned by chance

tirzepatide 10 mg
placebo

Reported lower percent change in body weight from baseline to week 72, no range given−12.4

randomised

Among Japanese participants with obesity and type 2 diabetes (T2D) from SURMOUNT-2 trial, the trial randomly assignedassigned by chance

tirzepatide 15 mg
placebo

Reported lower percent change in body weight from baseline to week 72, no range given−10.2

randomised

the abstract, start to end

15 mg (p = 0.013) compared with placebo: -12.4% (1.8%) and -10.2% (1.8%), respectively, compared

← favours treatmentfavours comparator →
could be chance
No interval given · direction only, strength unknown
Mean percent change in body weight from baseline to week 72tirzepatide 10 mg vs placebo, in Japanese participants with obesity and type 2 diabetes (T2D) from SURMOUNT-2 trial
−12.4
Mean percent change in body weight from baseline to week 72tirzepatide 15 mg vs placebo, in Japanese participants with obesity and type 2 diabetes (T2D) from SURMOUNT-2 trial
−10.2
GIP/GLP-1 & amylin agonistsBody weight & composition

GIP/GLP-1 & amylin agonists × body weight & compositionhelps?replicated

unlikelylikely
1.001.00 without it
← favours treatmentfavours comparator →
this papermore certainless certain
1 / 6

3 papers cite it

2025
2026
this papertrialcites it
Full record →Abstract, authors, funding and every citing paper · PMID 40490415