SGLT2 inhibitors × lipids

TrialBMC research notes2025

Comparison of the effects of empagliflozin and sitagliptin, as an add-on to metformin, on cardio-metabolic and glycemic parameters of patients with type 2 diabetes mellitus: a randomized, double-blind clinical trial.

Naimeh Mesri Alamdari et al.PubMed ↗Full text ↗Publisher ↗

  • Empagliflozincuts both waysHigher triglyceride levels, lower diastolic blood pressure, higher HDL cholesterol.Randomised, small.

What the trial testedrandomised · 2025

Randomised vs metformin

Probably raised triglyceride levels

+12.9mg/dl+6.00 to +31.8

empagliflozin vs metformin

As reported

difference 12.91 mg/dl, 95% CI 6.00–31.8

Randomised vs metformin

Probably lowered diastolic blood pressure

−13.4mm Hg−16.4 to −10.3

empagliflozin vs metformin

As reported

difference −13.4 mm Hg, 95% CI −16.4 to −10.3 · the paper's word: DBP

Randomised vs metformin

Probably raised HDL cholesterol

+6.47mg/dl+2.93 to +10.0

empagliflozin vs metformin

As reported

difference 6.47 mg/dl, 95% CI 2.93–10.0 · the paper's word: high-density lipoprotein (HDL-c) levels

No range given

Reported lower weight, no range given

−4.10

empagliflozin vs metformin

As reported

difference −4.1, no interval

+4 more in the walkthrough ↓

Who was studied, and how

people with type 2 diabetes, in this paper

The trial randomly assignedassigned by chance

empagliflozin
metformin

Probably raised triglyceride levels+12.9

Probably lowered diastolic blood pressure−13.4

Probably raised HDL cholesterol+6.47

randomised

the abstract, start to end

sitagliptin, and metformin arm (-1.8, -1.35, -0.69%).

led to reductions in SBP about - 8.27 mm Hg (95% CI: -13.31, -3.23; P = 0.001) and in DBP about - 13.37 mm Hg (95% CI: -16.42, -10.32;

group relative to the metformin group (-4.1 vs. -0.90 kg; p = 0.044).

in the empagliflozin group was - 12.91 mg/dl (95% CI: 31.82, 6; P = 0.001) for triglyceride (TG) levels and 6.47 mg/dl (95% CI: 2.93, 10.01;

← favours treatmentfavours comparator →
could be chance
No interval given · direction only, strength unknown
HbA1Cempagliflozin vs baseline
−1.8
HbA1Csitagliptin vs baseline
−1.35
HbA1Cmetformin vs baseline
−0.69
Blood pressure
−8.27−13.3 to −3.23
Weightempagliflozin vs metformin
−4.1
Triglyceride (TG) levelsempagliflozin vs metformin
12.916.00–31.8
DBPempagliflozin vs metformin
−13.4−16.4 to −10.3
High-density lipoprotein (HDL-c) levelsempagliflozin vs metformin
6.472.93–10.0
MetforminSGLT2 inhibitorsDPP-4 inhibitorsGlycemic controlBody weight & compositionLipidsBlood pressure
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1 paper cites it

2025
2026
this paperpooled itcites it
Full record →Abstract, authors, funding and every citing paper · PMID 40745313