ArticleLipids in health and disease2025
Global variations in omega-3 fatty acid status and omega-6:omega-3 ratios: insights from > 500,000 whole-blood dried blood spot samples.
Article in Lipids in health and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Polyunsaturated fatty acid (PUFA) supplementation and ADHD outcomes in children and adolescents: a systematic review and meta-analysis of randomized controlled trials.European child & adolescent psychiatry · 2026Review
- Polyunsaturated fatty acids modulation of smoking-related epigenetics and pulmonary outcomes.Genes & nutrition · 2026Article
- Basil and Cinnamon Essential Oils Improve Oxidative Stability and Fatty Acid Composition of Vegetable Oil Blends During Deep-Frying.Foods (Basel, Switzerland) · 2026Article
- Obesity is the culprit behind fatty acid-induced inflammation.Nutrition & metabolism · 2026Review
- Vitamin D and Omega-3 Supplementation for Emotional and Behavioral Dysregulation in Autism Spectrum Disorders: A Systematic Review.Journal of clinical medicine · 2026Review
- Plant-based diets for human health with implications for cardiometabolic health, gut microbiome, and nutritional adequacy.Frontiers in nutrition · 2026Review
- Rethinking the hepatoprotective potential of vegetarian diets in dysfunction-associated steatotic liver disease/metabolic-associated fatty liver disease: a critical narrative review.Frontiers in nutrition · 2026Review
- Polyunsaturated fatty acids and psychotic disorders: integrating mechanistic, genetic, and clinical evidence.Frontiers in nutrition · 2026Review
- The NMR-measured omega-6/omega-3 fatty acid ratio improves cardiovascular risk prediction.Frontiers in nutrition · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Omega-3 (n-3) fatty acids are critical for human health, with the omega-6 (n-6) to n-3 fatty acid ratio and the omega-3 levels recognized as contributing to the risk of many chronic non-communicable diseases. Direct measurement of fatty acid levels in blood provides the most accurate assessment of fatty acid status and balance, with fingertip dried blood spot (DBS) analysis offering a practical and cost-effective assessment method. This study analyses more than 590,000 globally sourced DBS samples, providing fatty acid profiles in whole blood across diverse populations. Results reveal significant global and demographic disparities in n-3 levels and n-6:n-3 ratios, with suboptimal n-3 levels and imbalanced n-6:n-3 ratios prevalent worldwide. While the findings align with general trends reported in previous global mapping studies on omega-3 status in red blood cells (RBC), they are based on whole blood measurements and highlight the utility of DBS testing for large-scale monitoring. These results underscore the need to enhance n-3 fatty acid intakes to help mitigate multiple global health challenges and demonstrate the utility of fingertip DBS testing as a practical approach to design dietary interventions to promote overall well-being.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.