← Statins × lipids

Observational studyCardiovascular diabetology2025

Lipoprotein levels and statin treatment related to dementia and cognitive decline in individuals with type 2 diabetes: an observational analysis from the ADVANCE study.

Peder Af Geijerstam et al.PubMed ↗Full text ↗Publisher ↗

  • Baseline LDL cholesterolno clear effectNo clear link with dementia/CD.Correlation only, not a test of it.
  • Statin treatmentno clear effectNo clear link with dementia/CD.Correlation only, not a test of it.

What moved togetherboth groups pooled, not the treatment’s effect

Correlation · may be no link

No clear link with dementia/CD

+6%+0% to +14%

baseline LDL cholesterol vs per standard deviation higher

Bigger than 1 in 10 on the map

As reported

OR 1.06, 95% CI 1.00–1.14

Correlation · may be no link

No clear link with dementia/CD

−10%−21% to +3%

statin treatment vs without statin treatment

Bigger than 2 in 10 on the map

As reported

OR 0.90, 95% CI 0.79–1.03

Who was studied, and how

11,140people with dyslipidemia, in this paper

Already taking baseline LDL cholesterol, or nottheir own situation, not assigned

on baseline LDL cholesterol
per standard deviation higher

No clear link with dementia/CD+6%

correlation, not a test

Already taking statin treatment, or nottheir own situation, not assigned

on statin treatment
without statin treatment

No clear link with dementia/CD−10%

correlation, not a test

the abstract, start to end

The OR (95% CI) of dementia/CD were 1.06 (1.00-1.14) per standard deviation higher in baseline LDL cholesterol and 0.90 (0.79-1.03) for participants …

← favours treatmentfavours comparator →
could be chance
Dementia/CDbaseline LDL cholesterol vs per standard deviation higher
OR 1.061.00–1.14
Dementia/CDstatin treatment vs without statin treatment
OR 0.900.79–1.03
StatinsLipids
1 / 4

1 paper cites it

2025
this papercites it
Full record →Abstract, authors, funding and every citing paper · PMID 40826451