Impact of GLP-1 Receptor Agonists on Suicide Behavior: A Meta-Analysis Based on Randomized Controlled Trials.

GLP-1 RA exposureno clear effectNo clear effect on suicidal behavior.Nothing cleared the noise.

What the trial testedas reported · 2025

Range includes no effect

−16%−46% to +32%

GLP-1 RA exposure vs control group

Bigger than 4 in 10 on the map

As reported

RR 0.84, 95% CI 0.54–1.32 · the paper's word: incidence of suicidal behavior

people with type 2 diabetes, in this paper

The trial randomly assignedassigned by chance

GLP-1 RA exposure

control group

No clear effect on suicidal behavior−16%

randomised

the abstract, start to end

… group and the control group (RR = 0.84, 95% CI: 0.54-1.32, p = 0.46, I …

← favours treatmentfavours comparator →

could be chance

Incidence of suicidal behaviorGLP-1 RA exposure vs control group

RR 0.840.54–1.32

GLP-1 receptor agonistsPharmacokinetics & dosing

GLP-1 receptor agonists × pharmacokinetics & dosinghelps?mixed

unlikelylikely

0.00not counted

← favours treatmentfavours comparator →

more certainless certain

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2025

2026

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