Insulin × glycemic control

SynthesisFrontiers in endocrinology2025

IDeglira vs insulin degludec for type 2 diabetes: a systematic review and meta-analysis.

Yang Liu et al.PubMed ↗Full text ↗Publisher ↗

  • IDegLiralooks good hereLower long-term blood sugar, lower body weight, lower fasting blood sugar.Randomised, large.

What the trial testedrandomised · 3,393 people · 2025

Randomised vs insulin degludec

Lowered long-term blood sugar

−0.79percentage points−1.03 to −0.54

IDegLira vs insulin degludec

As reported

difference −0.79 %, 95% CI −1.03 to −0.54 · the paper's word: HbA1c

Randomised vs insulin degludec

Lowered body weight

−1.62kg−2.13 to −1.11

IDegLira vs insulin degludec

As reported

difference −1.62 kg, 95% CI −2.13 to −1.11

Randomised vs insulin degludec

Lowered fasting blood sugar

−0.45mmol/L−0.77 to −0.14

IDegLira vs insulin degludec

As reported

difference −0.45 mmol/L, 95% CI −0.77 to −0.14 · the paper's word: fasting plasma glucose

Randomised vs insulin degludec

Lowered self-measured plasma glucose

−1.00mmol/L−1.42 to −0.59

IDegLira vs insulin degludec

As reported

difference −1.00 mmol/L, 95% CI −1.42 to −0.59

+1 more in the walkthrough ↓

Who was studied, and how

3,393people with obesity, in this paper

The trial randomly assignedassigned by chance

IDegLira
insulin degludec

Lowered long-term blood sugar−0.79

Lowered body weight−1.62

Lowered fasting blood sugar−0.45

randomised

the abstract, start to end

in significant reductions in HbA1c (MD -0.79%, 95%CI: -1.03% to -0.54%), body weight (MD -1.62 kg, 95% CI: -2.13 kg to -1.11 kg), fasting plasma glucose (MD -0.45 mmol/L, 95% CI: -0.77 mmol/L to -0.14 mmol/L), self-measured plasma glucose (MD -1.00 mmol/L, 95% CI: -1.42 mmol/L to -0.59 mmol/L), and systolic blood pressure (MD -2.23 mmHg, 95% CI: -3.63 mmHg to

← favours treatmentfavours comparator →
could be chance
HbA1cIDegLira vs insulin degludec
−0.79−1.03 to −0.54
Body weightIDegLira vs insulin degludec
−1.62−2.13 to −1.11
Fasting plasma glucoseIDegLira vs insulin degludec
−0.45−0.77 to −0.14
Self-measured plasma glucoseIDegLira vs insulin degludec
−1.00−1.42 to −0.59
Systolic blood pressureIDegLira vs insulin degludec
−2.23−3.63 to −0.82
InsulinGlycemic controlBody weight & compositionBlood pressure
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1 paper cites it

2025
2026
this papertrialcites it
Full record →Abstract, authors, funding and every citing paper · PMID 40958912