Evidence map›Paper›PMID 41235302›Full record

ArticleFrontiers in nutrition2025

The NMR-measured omega-6/omega-3 fatty acid ratio improves cardiovascular risk prediction.

Youwei Huang, Xianzhou Lu, Yanyan Shen, Ying Liu, Qiqing Zeng, Xianrong Liu, Wenkai Bin, Meili Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Youwei HuangDepartment of Infections, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang, China.
Xianzhou LuDepartment of Hepatobiliary Surgery, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang, China.
Yanyan ShenDepartment of Ultrasound Medicine, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang, China.
Ying LiuDepartment of Ultrasound Medicine, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang, China.
Qiqing ZengDepartment of Ultrasound Medicine, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang, China.
Xianrong LiuDepartment of Hepatobiliary Surgery, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang, China.
Wenkai BinAnimal Injury and Poisoning Treatment Center, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang, China.
Meili LiDepartment of Cardiac Function, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Improving 10-year cardiovascular risk prediction beyond the established SCORE2 algorithm is a clinical need. The plasma omega-6/omega-3 (O6:O3) polyunsaturated fatty acid (PUFA) ratio, a marker of inflammatory balance, is a promising biomarker for enhancing risk stratification. We aimed to evaluate if adding the O6:O3 ratio to the SCORE2 model improves the prediction of major adverse cardiovascular events (MACE). Methods: We conducted a prospective cohort study of 183,230 UK Biobank participants (aged 50-69 years, free of baseline cardiovascular disease or diabetes). The plasma O6:O3 ratio was measured by nuclear magnetic resonance (NMR) spectroscopy. We compared the predictive performance of the SCORE2 model with and without the O6:O3 ratio in an independent validation cohort ( Results: In the validation set, adding the O6:O3 ratio to SCORE2 significantly increased the C-index from 0.742 (95% CI: 0.738-0.746) to 0.747 (95% CI: 0.743-0.751) ( Conclusion: Incorporating the plasma O6:O3 PUFA ratio provides a modest but statistically significant improvement in 10-year MACE risk prediction with the SCORE2 algorithm. As a modifiable biomarker, the O6:O3 ratio holds potential to refine risk stratification and guide personalized nutritional interventions.

Indexed as

CVDfatty acidsmetabolomicsprediction modelSCORE2

Identifiers

PMID41235302
PMCPMC12605120

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.