Effects of Semaglutide on Body Composition and GFR: A Prespecified Analysis of the SMART Trial.

What the trial testedrandomised · 101 people · 2026

Randomised comparison

−9.10−11.0 to −7.20

As reported

difference −9.1, 95% CI −11.0 to −7.20

Randomised comparison

−0.90−1.60 to −0.10

As reported

difference −0.9, 95% CI −1.60 to −0.10

the abstract, start to end

… weight, lean body mass, and fat mass by -9.1 (95% confidence interval [CI], …

… extracellular water and systolic BP by -0.9 (95% CI, -1.6 to -0.1) L and …

← favours treatmentfavours comparator →

could be chance

Body weight & composition

−9.1−11.0 to −7.20

Blood pressure

−0.9−1.60 to −0.10

GLP-1 receptor agonistsBody weight & compositionBlood pressure

GLP-1 receptor agonists × blood pressurehelps?mixed

unlikelylikely

0.500.50 without it

GLP-1 receptor agonists × body weight & compositionhelps?replicated

unlikelylikely

0.900.90 without it

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this papermore certainless certain

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2026

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