Evidence map›Paper›PMID 6761214›Full record

ArticleDiabetes1982

Insulin resistance is a prominent feature of insulin-dependent diabetes.

R A DeFronzo, R Hendler, D Simonson

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Diabetes, 1982. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04133922 (Effect of GLP-1 on Microvascular Insulin Responses in Type 1 Diabetes), which is not on this map. Cited by 117 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
117citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04133922 early_phase1withdrawnstarted 2019, after this paper: background citation

Effect of GLP-1 on Microvascular Insulin Responses in Type 1 Diabetes

Ran2019Enrolled0Registered outcomes5Posted comparisons0ConditionsInsulin Sensitivity/Resistance, Type 1 DiabetesArmsDextrose 20 % in Water, GLP-1, Insulin
Open the trial in the graph
3 · Its place in the literature

Who cites it

117 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Improvement in insulin sensitivity after human islet transplantation for type 1 diabetes.The Journal of clinical endocrinology and metabolism · 2013
    Trial
  4. Trial
  5. Trial
  6. Albumin-corrected anion gap and risk of mortality among US adults.Archives of public health = Archives belges de sante publique · 2025
    Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
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  16. Article
  17. Characterizing skeletal muscle dysfunction in women with polycystic ovary syndrome.Therapeutic advances in endocrinology and metabolism · 2022
    Review
  18. Article
  19. Article
  20. Article

57 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

R A DeFronzo
R Hendler
D Simonson

Funding

ZIPRASIDONE IN TOURETTES SYNDROME, OBSESSIVE COMPULSIVE &PERVASIVE DEV. DISORDERM01RR000125 · NCRR · YALE UNIVERSITY · PI ALPERN, ROBERT J · 1985 to 2006
$24.1M
REGULATION OF HEPATIC AND PERIPHERAL GLUCOSE METABOLISMR01AM024092 · AM · YALE UNIVERSITY · PI DEFRONZO, RALPH A · 1985 to 1985
–
NCRR NIH HHS RR 00125NIADDK NIH HHS AM 24092
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Insulin ResistanceAdolescentAdultBlood GlucoseDiabetes Mellitus, Type 1FemaleHumansInsulinInsulin AntibodiesMaleMiddle AgedBlood GlucoseInsulinInsulin Antibodies

Identifiers

PMID6761214

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.