ArticleJournal of the neurological sciences1995
Brain MRI findings and cognitive impairment in patients undergoing chronic hemodialysis treatment.
Article in Journal of the neurological sciences, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 62 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Trial of Statin Holiday in Patients Receiving Maintenance Dialysis
Randomised Controlled Trial of Dialysate Cooling for the Preservation of Cognitive Function in People Receiving Haemodialysis
Who cites it
62 citing papers in PubMed, 1 synthesis or guideline pooled it, 165 citations in OpenAlex.
- Systematic review of structural and functional neuroimaging findings in children and adults with CKD.Clinical journal of the American Society of Nephrology : CJASN · 2013Pooled it
- Trial
- Effect of a home based, low intensity, physical exercise program in older adults dialysis patients: a secondary analysis of the EXCITE trial.BMC geriatrics · 2018Trial
- Randomized clinical trial of dialysate cooling and effects on brain white matter.Journal of the American Society of Nephrology : JASN · 2015Trial
- Rationale and design of a multi-centre randomised controlled trial of individualised cooled dialysate to prevent left ventricular systolic dysfunction in haemodialysis patients.BMC nephrology · 2012Trial
- Diagnostic Value and Clinical Significance of Temporopolar White-Matter Hyperintensities in CADASIL and Sporadic Small-Vessel Disease.Journal of clinical neurology (Seoul, Korea) · 2026Article
- Intradialytic cerebral blood flow reduction occurs irrespective of vascular access type: a comparative study.BMC nephrology · 2026Article
- The Clock Drawing Task reveals executive dysfunction in the dialysis population - an underrecognized and underestimated problem.Renal failure · 2024Article
- Article
- Characterization of diffusion MRI using the mean apparent propagator model in hemodialysis patients: A pilot study.Magnetic resonance imaging · 2023Article
- Dialysis adequacy and hemoglobin levels predict cerebral atrophy in maintenance-hemodialysis patients.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Microemboli induced by air bubbles may be deposited in organs as a consequence of contamination during medical care.Clinical kidney journal · 2023Article
- Neuropsychological Assessment of Cognitive Impairment in Kidney Transplantation (NAsKiT) and its related risk factors: a study protocol.Journal of nephrology · 2022Article
- Association of Serum GFAP with Functional and Neurocognitive Outcome in Sporadic Small Vessel Disease.Biomedicines · 2022Article
- Assessment of cognitive impairment and related risk factors in hemodialysis patients.Journal of nephrology · 2022Article
- Article
- Covert vascular brain injury in chronic kidney disease.Frontiers in neurology · 2022Review
- The instant impact of a single hemodialysis session on brain morphological measurements in patients with end-stage renal disease.Frontiers in human neuroscience · 2022Article
- Effects of Intradialytic Cognitive and Physical Exercise Training on Cognitive and Physical Abilities in Hemodialysis Patients: Study Protocol for a Randomized Controlled Trial.Frontiers in psychology · 2022Article
- Risk factors for intradialytic decline in cerebral perfusion and impaired cerebral autoregulation in adults on hemodialysis.Hemodialysis international. International Symposium on Home Hemodialysis · 2022Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although both morphologic cerebral damage and cognitive dysfunction are known to occur in patients on chronic hemodialysis (CHD) their extent and possible relation have been rarely studied. We therefore performed magnetic resonance imaging of the brain and neuropsychological testing in 30 consecutive CHD patients (mean age 58 years; range 37-69) and in an equal number of asymptomatic volunteers matched for age, sex and major cerebrovascular risk factors. Twenty-four (80%) of the CHD patients were demented according to the criteria of the Diagnostic and Statistical Manual of Mental Disorders IIIR and their mean scores on the Mini Mental State Examination (22.9 +/- 4 vs. 27.9 +/- 1.4; p < 0.001) and Mattis Dementia Rating Scale (112.3 +/- 21.5 vs. 141.9 +/- 2.3); p < 0.001) were significantly lower than those of controls. The brains of CHD patients showed significantly more atrophy on visual rating and semiquantitative morphometric measures. Multiple lacunes or confluent white matter hyperintensities predominated in 10 (33%) patients, three showed territorial infarcts and two a combination of both. Clinically these findings were unexpected in almost half of individuals. Marked cognitive impairment was associated with more extensive enlargement of the third ventricle (5.8 +/- 1.8 vs. 7.3 +/- 2 mm; p < 0.04) and the temporal horns (3.5 +/- 1.6 vs. 5.1 +/- 1.8 mm; p < 0.02) but not with the presence of cerebral ischemic lesions or any difference in laboratory data. These results call attention to a very high rate of cerebral damage in individuals undergoing CHD and suggest brain degeneration of probably toxic-metabolic etiology to be associated with severe cognitive impairment of these patients.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.