ArticleAmerican journal of kidney diseases : the official journal of the National Kidney Foundation1997
Prevalence, recognition, and implications of mental impairment among hemodialysis patients.
Article in American journal of kidney diseases : the official journal of the National Kidney Foundation, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03663049 (Trial of Statin Holiday in Patients Receiving Maintenance Dialysis), which is not on this map. Cited by 121 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Trial of Statin Holiday in Patients Receiving Maintenance Dialysis
Who cites it
121 citing papers in PubMed, 1 synthesis or guideline pooled it, 272 citations in OpenAlex.
- Physical exercise and cognitive training interventions to improve cognition in hemodialysis patients: A systematic review.Frontiers in public health · 2022Pooled it
- Effects of sodium bicarbonate therapy on cognitive and cerebrovascular function in midlife and older adults with chronic kidney disease: a pilot randomized trial.BMC nephrology · 2025Trial
- Association of Cognitive Function Screening Results with Adherence and Performance in a Pedometer-Based Intervention.American journal of nephrology · 2021Trial
- Trial
- Effect of a home based, low intensity, physical exercise program in older adults dialysis patients: a secondary analysis of the EXCITE trial.BMC geriatrics · 2018Trial
- Trial
- FGF-23 and cognitive performance in hemodialysis patients.Hemodialysis international. International Symposium on Home Hemodialysis · 2014Trial
- Effect of more frequent hemodialysis on cognitive function in the frequent hemodialysis network trials.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2013Trial
- Homocysteine lowering and cognition in CKD: the Veterans Affairs homocysteine study.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2009Trial
- Improving quality of life in older dialysis patients: the case for broader functional assessment.Clinical kidney journal · 2026Article
- Article
- Review
- Chronic kidney disease and cardiac remodeling potentiate cognitive impairment progression: disentangling the sex-specific cross talk of kidney-heart-brain axis.American journal of physiology. Heart and circulatory physiology · 2026Article
- Exploring the Cognitive Profiles of Haemodialysis Patients using Objective and Subjective Indicators: A Cross-sectional Observational Study.International journal of behavioral medicine · 2025Observational
- Article
- Why High-Volume Post-Dilution Hemodiafiltration Should Be the New Standard in Dialysis Care: A Comprehensive Review of Clinical Outcomes and Mechanisms.Journal of clinical medicine · 2025Review
- Patient and Health Care Provider Perspectives of Cognitive Difficulties in Dialysis.Kidney international reports · 2025Article
- Habitat analysis of iron deposition in the basal ganglia for diagnosing cognitive impairment in chronic kidney disease: evidence from a case-control study.BMC medical imaging · 2025Observational
- Care pathways for patients with cognitive impairment and chronic kidney disease.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025Review
- Cognitive impairment in CKD patients: a guidance document by the CONNECT network.Clinical kidney journal · 2025Review
61 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
The increasing age and co-morbidity of dialysis patients may be associated with an increase in the prevalence of Alzheimer's disease, stroke, and other causes of mental impairment. We sought to determine the prevalence, recognition, and implications of mental impairment among chronic hemodialysis patients. We administered the Mini Mental Status Exam (MMSE) to 336 randomly selected patients from three dialysis units. To determine recognition of mental impairment by health care providers, we compared MMSE scores with mental status assessments obtained from each patient's dialysis technician and medical record. To determine the clinical implications of mental impairment, we prospectively obtained Kt/V, albumin, protein catabolic rate, blood pressure, and hematocrit values. To determine the resource implications of mental impairment, we assessed staff time required to care for each patient as well as hospitalizations. We found that 22% of subjects had mild mental impairment (MMSE 18 to 23) and that 8% had moderate-severe mental impairment (MMSE 0 to 17). The sensitivity of technician and medical record mental status assessments were 57% and 15%, respectively. After adjusting for demographic and medical variables, low MMSE score was independently associated with low protein catabolic rate (odds ratio, 1.5; P = 0.02), increased technician time caring for patient after dialysis (odds ratio, 1.5; P = 0.005), and increased hospital days (odds ratio, 1.4; P = 0.03). In conclusion, there is a high prevalence of unrecognized mental impairment among hemodialysis patients that has adverse implications for protein nutritional status, staff time, and hospitalization. We recommend that clinicians routinely screen for mental impairment and target impaired patients for interventions to improve mental status and associated adverse outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.