Trial reportLipids1998
Low-fat, monounsaturate-rich diets reduce susceptibility of low density lipoproteins to peroxidation ex vivo.
Trial report in Lipids, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Low-fat diets for acquired hypercholesterolaemia.The Cochrane database of systematic reviews · 2011Pooled it
- Effects of high-fat and low-fat diets rich in monounsaturated fatty acids on serum lipids, LDL size and indices of lipid peroxidation in healthy non-obese men and women when consumed under controlled conditions.European journal of nutrition · 2011Trial
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oxidative modification of low density lipoprotein (LDL) plays an important role in the process of atherosclerosis. The susceptibility of LDL to oxidation and the amount of peroxidation products formed are influenced by the lipoprotein content of 18:1n-9, 18:2n-6, and the 18:2n-6/18:1n-9 ratio, which is dependent in part on dietary fatty acids. The purpose of this study was to determine if changing from a typical American diet to a low-fat, monounsaturate-rich diet (LFMR) would result in favorable alterations in the fatty acid composition and oxidative profile of LDL in hypercholesterolemic individuals. Free-living postmenopausal hypercholesterolemic women who routinely consumed a diet moderately high in total fat and total saturates (34 and 11%, respectively) followed an LFMR diet (26% fat, 6% saturated fat, and 14% monounsaturated fat) for 6 mon. Sixteen postmenopausal hypercholesterolemic women already following standard low-fat (LF) diets acted as a control for seasonal variations in serum lipids. LDL from randomly selected subjects (LF n = 6, LFMR n = 5) was evaluated. LFMR diets resulted in LDL with increased concentrations and percentages of 18:1n-9, reduced 18:2n-6/18:1n-9 ratio, and lower percentages of 18:2n-6. No significant changes in LDL fatty acids occurred in the LF group. Conjugated diene lag time increased in both groups during copper-induced in vitro oxidation. Only the LFMR group experienced an increase in lipid peroxide lag time and a decrease in lipid peroxide formation. The LFMR diet was well tolerated and may be of therapeutic value in the treatment of hypercholesterolemia.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.