Some answers, more controversy, from UKPDS. United Kingdom Prospective Diabetes Study.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

39 citing papers in PubMed, 7 syntheses or guidelines pooled it.

1. Efficacy and safety of insulin in type 2 diabetes: meta-analysis of randomised controlled trials.BMC endocrine disorders · 2016
   Pooled it
2. Are concomitant treatments confounding factors in randomized controlled trials on intensive blood-glucose control in type 2 diabetes? a systematic review.BMC medical research methodology · 2013
   Pooled it
3. Reappraisal of metformin efficacy in the treatment of type 2 diabetes: a meta-analysis of randomised controlled trials.PLoS medicine · 2012 · on this map
   Pooled it
4. Dipeptidyl peptidase-4 (DPP-4) inhibitors for type 2 diabetes mellitus.The Cochrane database of systematic reviews · 2008
   Pooled it
5. Emerging role of dipeptidyl peptidase-4 inhibitors in the management of type 2 diabetes.Vascular health and risk management · 2008
   Pooled it
6. Rosiglitazone for type 2 diabetes mellitus.The Cochrane database of systematic reviews · 2007
   Pooled it
7. Pioglitazone for type 2 diabetes mellitus.The Cochrane database of systematic reviews · 2006 · on this map
   Pooled it
8. Acute Administration of Metformin Protects Against Neuronal Apoptosis Induced by Cerebral Ischemia-Reperfusion InjuryFrontiers in pharmacology · 2022
   Article
9. Therapeutic potentials of agonist and antagonist of adenosine receptors in type 2 diabetes.Reviews in endocrine & metabolic disorders · 2021
   Review
10. Metformin as a modulator of myocardial fibrosis postmyocardial infarction via regulation of cardiomyocyte-fibroblast crosstalk.Translational research : the journal of laboratory and clinical medicine · 2018
    Article
11. Cardiovascular effects of anti-diabetes drugs.Expert opinion on drug safety · 2016
    Review
12. Severe Hypoglycemia Requiring Medical Intervention in a Large Cohort of Adults With Diabetes Receiving Care in U.S. Integrated Health Care Delivery Systems: 2005-2011.Diabetes care · 2016
    Observational
13. Chronic Metformin Preconditioning Provides Neuroprotection via Suppression of NF-κB-Mediated Inflammatory Pathway in Rats with Permanent Cerebral Ischemia.Molecular neurobiology · 2015
    Article
14. Impact of insulin treatment in diabetic macular edema therapy in type 2 diabetes.Canadian journal of diabetes · 2015
    Article
15. Acute metformin preconditioning confers neuroprotection against focal cerebral ischaemia by pre-activation of AMPK-dependent autophagy.British journal of pharmacology · 2014
    Article
16. Cellular dysfunction in diabetes as maladaptive response to mitochondrial oxidative stress.Experimental diabetes research · 2012
    Review
17. Oxidative stress and glycaemic control in type 2 diabetic patients in enugu, South-East Nigeria.Annals of medical and health sciences research · 2011
    Article
18. Influence of intensive versus conventional glucose control on microvascular and macrovascular complications in type 1 and 2 diabetes mellitus.Drugs · 2010
    Review
19. A cardiologic approach to non-insulin antidiabetic pharmacotherapy in patients with heart disease.Cardiovascular diabetology · 2009
    Review
20. Stickiness of the blues: Chronicity of depression.Indian journal of psychiatry · 2009
    Article

Corrections and comments

• Comment on
  Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group.1998
• Comment on
  Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group.1998

Authors and funding

1 author.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

Indexed as