Evidence map›Paper›PMID 14688154›Full record

ReviewHuman reproduction (Oxford, England)2004

Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS).

Rotterdam ESHRE/ASRM-Sponsored PCOS consensus workshop group

15 registry-linked trialsAbstract readReview
PubMed Publisher
In one paragraph

Review in Human reproduction (Oxford, England), 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 15 registered trials, which are not on this map. Cited by 2,058 papers, 18 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2,058citing papers in PubMed, 18 pooled it
89.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03151005 phase4completedstarted 2017, after this paper: background citation

Randomized Clinical Trial to Evaluate The Effect of Metformin-GLP-1 Receptor Agonist Versus Oral Contraceptive (OC) Therapy on Reproductive Disorders and Cardiovascular Risks in Overweight Polycystic Ovarian Syndrome (PCOS) Patients

Ran2017Enrolled70Registered outcomes5Posted comparisons0ConditionsObesity, Overweight, Polycystic Ovary Syndrome (PCOS)ArmsMetformin-GLP-1 Receptor Agonist, Metformin-Oral Contraceptive(OC)
PMID 28646699PMID 28860713PMID 24389146PMID 22777527PMID 30459598PMID 29569621PMID 28463030PMID 26426951PMID 20471009PMID 12046553other papers from this trial
Open the trial in the graph
NCT05952882 phase3unknown statusstarted 2023, after this paper: background citation

Effectiveness of the Combination Liraglutide and Metformin on Weight Loss, Metabolic - Endocrine Parameters and Pregnancy Rate in Women With Polycystic Ovarian Syndrome, Obesity and Infertility

Ran2023Enrolled188Registered outcomes60Posted comparisons0ConditionsInfertility, Female, Obesity, Polycystic Ovary SyndromeArmsLiraglutide + metformin, Metformin
PMID 18364705PMID 28681988PMID 19056992PMID 31229399PMID 29703793PMID 19841045PMID 31733195PMID 24362411PMID 17980364PMID 18068166PMID 22767467PMID 24151290other papers from this trial
Open the trial in the graph
NCT00679679 phase4completednot on this map

Clinical Metabolic and Endocrine Parameters in Response to Metformin and Lifestyle Intervention in Women With Polycystic Ovary Syndrome: A Phase 4 Randomized, Double- Blind and Placebo Control Trial

TypeinterventionalSponsorHospital Privado de Cordoba, ArgentinaRan2003 to 2005Enrolled30ConditionsPolycystic Ovary SyndromeArmsMetformin, Placebo
NCT02190006 unknown statusnot on this mapstarted 2014, after this paper: background citation

Comparison Between the Role of Follicular Output Rate and Preovulatory Count in the Prediction of Pregnancy in Women With Polycystic Ovarian Syndrome Undergoing Intra Cytoplasmic Sperm Injection (ICSI)

TypeobservationalSponsorCairo UniversityRan2014 to 2017Enrolled300ConditionsPolycystic Ovarian Syndrome, Subfertility, ICSI
NCT02385396 phase2completednot on this map

Evaluation Concerning the Influence of Myo-inositol Therapy on the Dynamics of Embryo Development in Patients Suffering From PCOS Undergoing ICSI Treatment

TypeinterventionalSponsorMedical University of LublinEnrolled217ConditionsPolycystic Ovary Syndrome, InfertilityArmsInofolic: myo-inositol and folic acid
NCT02803476 unknown statusnot on this mapstarted 2016, after this paper: background citation

Is There An Association Between Vitamin D Levels And Insulin Resistance In Polycystic Ovary Syndrome?

TypeobservationalSponsorAin Shams Maternity HospitalRan2016 to 2016Enrolled166ConditionsPolycystic Ovary Syndrome, Insulin Resistance, Vitamin D Deficiency
NCT03264638 phase2unknown statusnot on this mapstarted 2016, after this paper: background citation

A Clinical and Biological Research of Combined Chinese and Western Medicine in the Treatment of Polycystic Ovary Syndrome

TypeinterventionalSponsorAijun SunRan2016 to 2018Enrolled315ConditionsPCOSArmsDingkundan, Dingkundan & Diane-35, Diane-35
NCT04881851 naterminatednot on this mapstarted 2015, after this paper: background citation

Effects of Inositol Alone or Associated With Alpha-lipoic Acid in Polycystic Ovary Syndrome Treatment

TypeinterventionalSponsorUniversita di VeronaRan2015 to 2025Enrolled76ConditionsPolycystic Ovary SyndromeArmsInositol + alpha lipoic acid, Inositol, Folic acid (placebo comparator)
NCT05410834 unknown statusnot on this mapstarted 2022, after this paper: background citation

The Characterization of Pro-vascular Regenerative Cell Exhaustion in Women With Polycystic Ovarian Syndrome

TypeobservationalSponsorCanadian Medical and Surgical Knowledge Translation Research GroupRan2022 to 2023Enrolled30ConditionsPolycystic Ovary Syndrome
NCT06367985 nacompletednot on this mapstarted 2024, after this paper: background citation

CAPA-IVM Culture With Low Oxygen Tension

TypeinterventionalSponsorMỹ Đức HospitalRan2024 to 2025Enrolled20ConditionsIn Vitro FertilizationArmsAir Oxygen Concentration CAPA-IVM culture, Low Oxygen Concentration CAPA-IVM culture
NCT06545721 narecruitingnot on this mapstarted 2024, after this paper: background citation

The Effect and Mechanism Of Weight Cycling on Hyperandrogenemia And Insulin Resistance in Polycystic Ovary Syndrome

TypeinterventionalSponsorPeking Union Medical College HospitalRan2024 to 2026Enrolled425ConditionsPolycystic Ovary SyndromeArmsAdjusting dietary structure + exercise + behavioral intervention, Precision dietary prescription, Standard guideline-based low-energy diet
NCT06766604 narecruitingnot on this mapstarted 2025, after this paper: background citation

Exploratory In-vitro Study Evaluating the Addition of Super-GDF9 During Capacitation-in-vitro Maturation (CAPA-IVM) of Donated Human Cumulus-oocyte Complexes (COCs) Derived From Small Antral Follicles

TypeinterventionalSponsorMỹ Đức HospitalRan2025 to 2026Enrolled9ConditionsIn Vitro FertilizationArmsSuper-GDF9 supplementation during CAPA-IVM, Conventional CAPA-IVM
NCT06836128 phase3recruitingnot on this mapstarted 2025, after this paper: background citation

The Combined Effect of N-Acetyl Cysteine and Metformin in Polycystic Ovary Syndrome Patients

TypeinterventionalSponsorCairo UniversityRan2025 to 2026Enrolled102ConditionsPolycystic Ovary SyndromeArmsN-acetyl cysteine, Metfomin
NCT07197255 recruitingnot on this mapstarted 2025, after this paper: background citation

Transcriptomic Profiling of Cumulus Cells From CAPA-IVM Cycles in Women With PCOS: A Prospective Pilot Study

TypeobservationalSponsorMỹ Đức HospitalRan2025 to 2026Enrolled10ConditionsPCOS (Polycystic Ovary Syndrome), Cumulus Cell, Capacitation IVM, Transcriptomic Profiling
NCT07687264 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

METabolic FLEXibility in PMOS

TypeinterventionalSponsorUniversity of ZurichRan2026 to 2029Enrolled40ConditionsPCOS (Polycystic Ovary Syndrome), Insulinemic Response, Overweight (BMI > 25)ArmsOral Clucose Tolerance Test (oGTT)
3 · Its place in the literature

Who cites it

2,058 citing papers in PubMed, 18 syntheses or guidelines pooled it, 5,975 citations in OpenAlex.

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1,998 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Rotterdam ESHRE/ASRM-Sponsored PCOS consensus workshop group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since the 1990 NIH-sponsored conference on polycystic ovary syndrome (PCOS), it has become appreciated that the syndrome encompasses a broader spectrum of signs and symptoms of ovarian dysfunction than those defined by the original diagnostic criteria. The 2003 Rotterdam consensus workshop concluded that PCOS is a syndrome of ovarian dysfunction along with the cardinal features hyperandrogenism and polycystic ovary (PCO) morphology. PCOS remains a syndrome and, as such, no single diagnostic criterion (such as hyperandrogenism or PCO) is sufficient for clinical diagnosis. Its clinical manifestations may include: menstrual irregularities, signs of androgen excess, and obesity. Insulin resistance and elevated serum LH levels are also common features in PCOS. PCOS is associated with an increased risk of type 2 diabetes and cardiovascular events.

Indexed as

Clinical Trials as TopicConsensus Development Conferences, NIH as TopicConsensus Statements as TopicFemaleHumansHyperandrogenismInsulin ResistanceLuteinizing HormonePolycystic Ovary SyndromeRisk FactorsUnited StatesLuteinizing Hormone

Identifiers

PMID14688154
OpenAlexW4256605237

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

and 9 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.