SynthesisBMJ (Clinical research ed.)2006
Strength of evidence for perioperative use of statins to reduce cardiovascular risk: systematic review of controlled studies.
Synthesis in BMJ (Clinical research ed.), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01543555 (Multicenter Randomized Controlled Trial of Loading Dose Statins for the Prevention of Cardiovascular Complications in High-Risk Non-Cardiac Surgery), which is not on this map. Cited by 21 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Multicenter Randomized Controlled Trial of Loading Dose Statins for the Prevention of Cardiovascular Complications in High-Risk Non-Cardiac Surgery
Open the trial in the graphWho cites it
21 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Preoperative statin therapy for adults undergoing cardiac surgery.The Cochrane database of systematic reviews · 2024Pooled it
- Effect of lipid-modifying therapy on long-term mortality after abdominal aortic aneurysm repair: a systemic review and meta-analysis.World journal of surgery · 2015Pooled it
- Perioperative statin therapy for improving outcomes during and after noncardiac vascular surgery.The Cochrane database of systematic reviews · 2013 · on this mapPooled it
- Perioperative use of statins in noncardiac surgery.Vascular health and risk management · 2008Pooled it
- Association between pre-operative statin use and major cardiovascular complications among patients undergoing non-cardiac surgery: the VISION study.European heart journal · 2016 · on this mapTrial
- Statin use in total joint arthroplasty: a systematic review.Annals of medicine and surgery (2012) · 2024Article
- Effects of perioperative statin use on cardiovascular complications in patients submitted to non-cardiac surgery: protocol for a systematic review, meta-analysis, and trial sequential analysis.Systematic reviews · 2017Article
- Effects of preoperative statin use on perioperative outcomes of carotid endarterectomy.Brain and behavior · 2017Article
- Minimizing cardiac risk in perioperative practice - interdisciplinary pharmacological approaches.Wiener klinische Wochenschrift · 2011Review
- [Perioperative management of long-term medication].Der Internist · 2011Article
- Short-term vascular risk: time to take notice?Nature reviews. Cardiology · 2010Review
- Non-invasive cardiac stress testing before elective major non-cardiac surgery: population based cohort study.BMJ (Clinical research ed.) · 2010Article
- Preadmission statin use and one-year mortality among patients in intensive care - a cohort study.Critical care (London, England) · 2010Article
- Perioperative medicine update.Journal of general internal medicine · 2009Article
- Treatment recommendations to prevent myocardial ischemia and infarction in patients undergoing vascular surgery.Current treatment options in cardiovascular medicine · 2009Article
- Delirium after elective surgery among elderly patients taking statins.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2008Article
- [Minimizing perioperative risk - an interdisciplinary effort].Wiener medizinische Wochenschrift (1946) · 2008Review
- Beta blockers and statins in non-cardiac surgery.BMJ (Clinical research ed.) · 2007Article
- The lesser known effects of statins: benefits on infectious outcomes may be explained by "healthy user" effect.BMJ (Clinical research ed.) · 2006Article
- Validation of a model to predict all-cause in-hospital mortality in vascular surgical patients.Cardiovascular journal of AfricaArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine the strength of evidence underlying recommendations for use of statins during the perioperative period to reduce the risk of cardiovascular events.
designSystematic review of studies with concurrent control groups. DATA SOURCES: Four electronic databases, the references of identified studies, international experts on perioperative medicine, and the authors of the primary studies. Review methods Two reviewers independently extracted data from studies that reported acute coronary syndromes or mortality in patients receiving or not receiving statins during the perioperative period.
main outcome measureRandom effects summary odds ratios for death or acute coronary syndrome during the perioperative period.
results18 studies--two randomised trials (n=177), 15 cohort studies (n=799,632), and one case-control study (n=480)--assessed whether statins provide perioperative cardiovascular protection; 12 studies enrolled patients undergoing non-cardiac vascular surgery, four enrolled patients undergoing coronary bypass surgery, and two enrolled patients undergoing various surgical procedures. In the randomised trials the summary odds ratio for death or acute coronary syndrome during the perioperative period with statin use was 0.26 (95% confidence interval 0.07 to 0.99) and the summary odds ratio in the cohort studies was 0.70 (0.57 to 0.87). Although the pooled cohort data provided a statistically significant result, statins were not randomly allocated, results in retrospective studies were larger (odds ratio 0.65, 0.50 to 0.84) than those in the prospective cohorts (0.91, 0.65 to 1.27), and dose, duration, and safety of statin use was not reported.
conclusionThe evidence base for routine administration of statins to reduce perioperative cardiovascular risk is inadequate.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.