GLP-1 receptor agonists × glycemic control

TrialDiabetic medicine : a journal of the British Diabetic Association2008

Liraglutide, a once-daily human GLP-1 analogue, improves pancreatic B-cell function and arginine-stimulated insulin secretion during hyperglycaemia in patients with Type 2 diabetes mellitus.

T Vilsbøll et al.PubMed ↗Publisher ↗

  • 1.25 mg/day liraglutideno clear effectHigher first-phase insulin secretion, no range given, higher arginine-stimulated insulin secretion, no range given.No ranges given.
  • 1.9 mg/day liraglutideno clear effectHigher first-phase insulin secretion, no range given, higher arginine-stimulated insulin secretion, no range given.No ranges given.

What the trial testedas reported · 39 people · 2008

No range given

Reported higher first-phase insulin secretion, no range given

+118

1.25 mg/day liraglutide vs placebo

As reported

difference 118, no interval

No range given

Reported higher first-phase insulin secretion, no range given

+103percentage points

1.9 mg/day liraglutide vs placebo

As reported

difference 103 %, no interval

No range given

Reported higher arginine-stimulated insulin secretion, no range given

+114

1.25 mg/day liraglutide vs placebo

As reported

difference 114, no interval

No range given

Reported higher arginine-stimulated insulin secretion, no range given

+94.0percentage points

1.9 mg/day liraglutide vs placebo

As reported

difference 94 %, no interval

Who was studied, and how

177people in the Effect of Liraglutide on Glycaemic Control in Subjects With Type 2 Diabetes. trial, from 2005
39of them with type 2 diabetes, in this paper

The trial randomly assignedassigned by chance

1.25 mg/day liraglutide
placebo

Reported higher first-phase insulin secretion, no range given+118

Reported higher arginine-stimulated insulin secretion, no range given+114

randomised

The trial randomly assignedassigned by chance

1.9 mg/day liraglutide
placebo

Reported higher first-phase insulin secretion, no range given+103

Reported higher arginine-stimulated insulin secretion, no range given+94.0

randomised

the abstract, start to end

first-phase insulin secretion by 118 and 103%, respectively (P < 0.05).

two highest dose levels vs. placebo by 114 and 94%, respectively (P < 0.05).

← favours treatmentfavours comparator →
could be chance
No interval given · direction only, strength unknown
First-phase insulin secretion1.25 mg/day liraglutide vs placebo
118
First-phase insulin secretion1.9 mg/day liraglutide vs placebo
103
Arginine-stimulated insulin secretion1.25 mg/day liraglutide vs placebo
114
Arginine-stimulated insulin secretion1.9 mg/day liraglutide vs placebo
94
GLP-1 receptor agonistsGlycemic control
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The trial

Full record →Abstract, authors, funding and every citing paper · PMID 18201212