Statins × all-cause mortality

TrialLancet (London, England)2008

Effect of rosuvastatin in patients with chronic heart failure (the GISSI-HF trial): a randomised, double-blind, placebo-controlled trial.

Luigi Tavazzi et al.PubMed ↗Publisher ↗

  • Rosuvastatin 10 mg dailyno clear effectNo clear effect on deaths from any cause, no clear effect on death or admission to hospital for cardiovascular reasons.Nothing cleared the noise.

What the trial testedas reported · 4,574 people · 2008

Range includes no effect

No clear effect on deaths from any cause

+0%−10% to +12%

rosuvastatin 10 mg daily vs placebo

29 in 100 instead of 28

Smaller than almost all for all-cause mortality

As reported

HR 1.00, 95% CI 0.90–1.12 · the paper's word: death from any cause

Range includes no effect

No clear effect on death or admission to hospital for cardiovascular reasons

+1%−9% to +11%

rosuvastatin 10 mg daily vs placebo

29 in 100 instead of 28

Smaller than almost all for all-cause mortality

As reported

HR 1.01, 95% CI 0.91–1.11

Who was studied, and how

6,975people in the A Large Scale Clinical Trial Testing the Effects of n-3 PUFA and Rosuvastatin on Mortality-Morbidity of Patients With Symptomatic Congestive Heart Failure trial, from 2002
4,574of them with heart failure, in this paper

The trial randomly assignedassigned by chance

rosuvastatin 10 mg daily
placebo

No clear effect on deaths from any cause+0%

No clear effect on death or admission to hospital for cardiovascular reasons+1%

randomised

the abstract, start to end

group (adjusted hazard ratio [HR] 1.00 [95.5% CI 0.898-1.122], p=0.943). 1305 (57%) patients in the rosuvastatin group and 1283 (56%) in the placebo group died or were admitted to hospital for cardiovascular reasons (adjusted HR 1.01 [99% CI 0.908-1.112], p=0.903).

← favours treatmentfavours comparator →
could be chance
Death from any causerosuvastatin 10 mg daily vs placebo
HR 1.000.90–1.12
Death or admission to hospital for cardiovascular reasonsrosuvastatin 10 mg daily vs placebo
HR 1.010.91–1.11
StatinsAll-cause mortality

Statins × all-cause mortalityhelps?mixed

unlikelylikely
0.500.50 without it
← favours treatmentfavours comparator →
this papermore certainless certain
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Full record →Abstract, authors, funding and every citing paper · PMID 18757089