Trial reportJournal of the American College of Cardiology2013
Simvastatin impairs exercise training adaptations.
Trial report in Journal of the American College of Cardiology, 2013. The graph read 1 number from its abstract, feeding 2 cells of the map, but none could be read as for or against, so it casts no vote. It reports registered trial NCT01700530. Cited by 97 papers, 1 of them a synthesis that pooled it.
What it found
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Cardiorespiratory fitness increased by 10% (p < 0.05) in response to exercise training alone, but was blunted by the addition of simvastatin resulting in only a 1.5% increase (p < 0.005 for group by time interaction).
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Where it lands on the map
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What it adds to each cell
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Diet, exercise & lifestyle×adverse events & safety
No readable resultOpen on the map →What to test next →1 readable study in this cell: 0 favour the treatment, 1 find no difference, 0 favour the comparator.
This paper's own estimate is on a different scale from the rest of the cell, so it is not drawn here.
Statins×adverse events & safety
No readable resultOpen on the map →What to test next →11 readable studies in this cell: 3 favour the treatment, 7 find no difference, 1 favour the comparator.
This paper's own estimate is on a different scale from the rest of the cell, so it is not drawn here.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Combined Effects of Statins and Exercise on Physiological Health Markers and Quality of Life in Patients With Dyslipidaemia
The Effects of Rosuvastatin on Physiological Adaptation and Safety During Regular Long-Distance Running Training: A Randomized Controlled Trial
Investigating the Role of Mechanical Muscle Loading in the Context of Preventive Exercise for Statin Users - a Pilot Study
Who cites it
97 citing papers in PubMed, 1 synthesis or guideline pooled it, 239 citations in OpenAlex.
- Statins, mood, sleep, and physical function: a systematic review.European journal of clinical pharmacology · 2014Pooled it
- The effects of high-intensity interval training versus continuous moderate-intensity exercise on body composition among older adults with HIV.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Trial
- Enhancement of Statin Effects on Lipid Lowering and Reduction of Cardiovascular Risk Score by (-)-Epicatechin in Proof-of-Concept Pilot Study.Clinical and translational science · 2025Trial
- Effects of a lifestyle intervention on cardiovascular risk factors in systemic lupus erythematosus patients: The study "Living well with lupus".Clinical rheumatology · 2024Trial
- The angiotensin-converting enzyme I/D polymorphism does not impact training-induced adaptations in exercise capacity in patients with stable coronary artery disease.Scientific reports · 2023Trial
- Statin Use Improves Cardiometabolic Protection Promoted By Physical Training in an Aquatic Environment: A Randomized Clinical Trial.Arquivos brasileiros de cardiologia · 2021Trial
- Moderate-Intensity Exercise and High-Intensity Interval Training Affect Insulin Sensitivity Similarly in Obese Adults.The Journal of clinical endocrinology and metabolism · 2020Trial
- Effects of statin therapy and exercise on postprandial triglycerides in overweight individuals with hypercholesterolaemia.British journal of clinical pharmacology · 2020Trial
- Individual Response Variation in the Effects of Weight Loss and Exercise on Insulin Sensitivity and Cardiometabolic Risk in Older Adults.Frontiers in endocrinology · 2020Trial
- A common missense variant of LILRB5 is associated with statin intolerance and myalgia.European heart journal · 2017 · on this mapTrial
- Benefits of a Paleolithic diet with and without supervised exercise on fat mass, insulin sensitivity, and glycemic control: a randomized controlled trial in individuals with type 2 diabetes.Diabetes/metabolism research and reviews · 2017Trial
- Trial
- Statins and Exercise Training Response in Heart Failure Patients: Insights From HF-ACTION.JACC. Heart failure · 2016Trial
- Effects of 96 Weeks of Rosuvastatin on Bone, Muscle, and Fat in HIV-Infected Adults on Effective Antiretroviral Therapy.AIDS research and human retroviruses · 2016Trial
- Evidence for metabolic aberrations in asymptomatic persons with type 2 diabetes after initiation of simvastatin therapy.Translational research : the journal of laboratory and clinical medicine · 2015Trial
- Trial
- One bout of exercise alters free-living postprandial glycemia in type 2 diabetes.Medicine and science in sports and exercise · 2014Trial
- Trial
- Essential amino acid supplementation in patients following total knee arthroplasty.The Journal of clinical investigation · 2013Trial
- Resveratrol blunts the positive effects of exercise training on cardiovascular health in aged men.The Journal of physiology · 2013Trial
37 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
Abstract
The marked sentences are the ones the graph read a number from.
objectivesThis study sought to determine if simvastatin impairs exercise training adaptations.
backgroundStatins are commonly prescribed in combination with therapeutic lifestyle changes, including exercise, to reduce cardiovascular disease risk in patients with metabolic syndrome. Statin use has been linked to skeletal muscle myopathy and impaired mitochondrial function, but it is unclear whether statin use alters adaptations to exercise training.
methodsThis study examined the effects of simvastatin on changes in cardiorespiratory fitness and skeletal muscle mitochondrial content in response to aerobic exercise training. Sedentary overweight or obese adults with at least 2 metabolic syndrome risk factors (defined according to National Cholesterol Education Panel Adult Treatment Panel III criteria) were randomized to 12 weeks of aerobic exercise training or to exercise in combination with simvastatin (40 mg/day). The primary outcomes were cardiorespiratory fitness and skeletal muscle (vastus lateralis) mitochondrial content (citrate synthase enzyme activity).
resultsThirty-seven participants (exercise plus statins: n = 18; exercise only: n = 19) completed the study. Cardiorespiratory fitness increased by 10% (p < 0.05) in response to exercise training alone, but was blunted by the addition of simvastatin resulting in only a 1.5% increase (p < 0.005 for group by time interaction). Similarly, skeletal muscle citrate synthase activity increased by 13% in the exercise-only group (p < 0.05), but decreased by 4.5% in the simvastatin-plus-exercise group (p < 0.05 for group-by-time interaction).
conclusionsSimvastatin attenuates increases in cardiorespiratory fitness and skeletal muscle mitochondrial content when combined with exercise training in overweight or obese patients at risk of the metabolic syndrome. (Exercise, Statins, and the Metabolic Syndrome; NCT01700530).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.