Statins × lipids

SynthesisLancet (London, England)2015

HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials.

Daniel I Swerdlow et al.PubMed ↗Full text ↗Publisher ↗

What the trial testedrandomised · 463 people · 2015

Randomised comparison

Probably lowered lipids

−0.92mmol/L−1.67 to −0.18

As reported

difference −0.92 mmol/L, 95% CI −1.67 to −0.18

Randomised comparison

Probably raised lipids

+0.24kg+0.10 to +0.38

As reported

difference 0.24 kg, 95% CI 0.10–0.38

Randomised comparison

Probably raised lipids

+12%+6% to +18%

Bigger than 2 in 10 on the map

As reported

OR 1.12, 95% CI 1.06–1.18

Three numbers in the abstract

the abstract, start to end

statins lowered LDL cholesterol by 0.92 mmol/L (95% CI 0.18-1.67) at 1-year of follow-up, increased bodyweight by 0.24 kg (95% CI 0.10-0.38 in all trials; 0.33 kg, 95% CI 0.24-0.42 in placebo or standard care controlled trials and -0.15 kg, 95% CI -0.39 to 0.08 in intensive-dose vs moderate-dose trials) at a mean of 4.2 years (range 1.9-6.7) of follow-up, and increased the odds of new-onset type 2 diabetes (OR 1.12, 95% CI 1.06-1.18 in all

← favours treatmentfavours comparator →
could be chance
Lipids
−0.92−1.67 to −0.18
Lipids
0.240.10–0.38
Lipids
OR 1.121.06–1.18
StatinsLipids

Statins × lipidshelps?mixed

unlikelylikely
0.50not counted
← favours treatmentfavours comparator →
more certainless certain
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The trial

Full record →Abstract, authors, funding and every citing paper · PMID 25262344