Evidence map›Paper›PMID 25523498›Full record

ArticleThe lancet. Diabetes & endocrinology2015

Possible adverse effects of SGLT2 inhibitors on bone.

Simeon I Taylor, Jenny E Blau, Kristina I Rother

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The lancet. Diabetes & endocrinology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02891954 (Pharmacogenomics to Predict Responses to SGLT2 Inhibitors), which is not on this map. Cited by 123 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
123citing papers in PubMed, 10 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02891954 phase1active not recruitingstarted 2016, after this paper: background citation

Pharmacogenomics to Predict Responses to SGLT2 Inhibitors

Ran2016Enrolled700Registered outcomes7Posted comparisons0ConditionsDiabetes Mellitus, Type 2ArmsCanagliflozin
PMID 29669938PMID 38481375PMID 38947416PMID 37738423PMID 31109940PMID 29875481PMID 26086329other papers from this trial
Open the trial in the graph
3 · Its place in the literature

Who cites it

123 citing papers in PubMed, 10 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Effect of SGLT2 inhibitors on fractures, BMD, and bone metabolism markers in patients with type 2 diabetes mellitus: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2023
    Pooled it
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  6. Treatment of Diabetes in Older Adults: An Endocrine Society* Clinical Practice Guideline.The Journal of clinical endocrinology and metabolism · 2019
    Guideline
  7. Fracture Risk After Initiation of Use of Canagliflozin: A Cohort Study.Annals of internal medicine · 2019 · on this map
    Pooled it
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  20. The effects of elevated phosphate on the kidney - damaging the gatekeeper.Pflugers Archiv : European journal of physiology · 2026
    Review

63 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Simeon I TaylorDiabetes, Endocrinology, and Obesity Branch, NIDDK, National Institutes of Health, Bethesda, MD 20892, USA; Division of Diabetes, Endocrinology, and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address: simeon.taylor@nih.gov.
Jenny E BlauDiabetes, Endocrinology, and Obesity Branch, NIDDK, National Institutes of Health, Bethesda, MD 20892, USA.
Kristina I RotherDiabetes, Endocrinology, and Obesity Branch, NIDDK, National Institutes of Health, Bethesda, MD 20892, USA.

Funding

Intramural NIH HHS Z99 DK999999
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Sodium-Glucose Transporter 2 InhibitorsBenzhydryl CompoundsFractures, BoneGlucosidesHumansHypoglycemic AgentsSodium-Glucose Transporter 2Benzhydryl CompoundsdapagliflozinGlucosidesHypoglycemic AgentsSLC5A2 protein, humanSodium-Glucose Transporter 2Sodium-Glucose Transporter 2 Inhibitors

Identifiers

PMID25523498
PMCPMC4900761

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.