GLP-1 receptor agonists × body weight & composition

SynthesisJournal of diabetes research2015

Effects of glucagon-like peptide-1 receptor agonists on weight loss in patients with type 2 diabetes: a systematic review and network meta-analysis.

Feng Sun et al.PubMed ↗Full text ↗Publisher ↗

What the trial testedrandomised · 17,521 people · 2015

Randomised comparison

Lowered body weight & composition

−1.07kg−2.41 to −0.02

As reported

difference −1.07 kg, 95% CI −2.41 to −0.02

Randomised comparison

Lowered body weight & composition

−5.30kg−6.38 to −4.24

As reported

difference −5.30 kg, 95% CI −6.38 to −4.24

Randomised comparison

Lowered hypoglycaemia

−7.30kg−12.8 to −1.78

As reported

difference −7.30 kg, 95% CI −12.8 to −1.78

Not counted

Lowered hypoglycaemia

−1.38kg−1.74 to −1.03

As reported

difference −1.38 kg, 95% CI −1.74 to −1.03

+1 more in the walkthrough ↓

Five numbers in the abstract

the abstract, start to end

treatment, with mean differences of -1.07 kg (95% CI: -2.41, -0.02),

reduction significantly ranged from -5.30 kg (95% CI: -6.38, -4.24) to

and LIR1.8QD decreased body weight by -1.38 kg (95% CI: -1.74, -1.03) and

drugs; the range of weight reduction was -7.30 kg (95% CI: -12.82,

versus placebo, with mean differences of -1.92 kg (95% CI: -2.61, -1.24) and

← favours treatmentfavours comparator →
could be chance
Body weight & composition
−1.07−2.41 to −0.02
Body weight & composition
−5.30−6.38 to −4.24
Hypoglycaemia
−1.38−1.74 to −1.03
Hypoglycaemia
−7.30−12.8 to −1.78
Glycemic control
−1.92−2.61 to −1.24
GLP-1 receptor agonistsInsulinGlycemic controlBody weight & compositionHypoglycaemia

GLP-1 receptor agonists × body weight & compositionhelps?replicated

unlikelylikely
0.90not counted

GLP-1 receptor agonists × hypoglycaemiaharms?mixed

unlikelylikely
0.50not counted
← favours treatmentfavours comparator →
more certainless certain
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