Statins × adverse events & safety

SynthesisEuropean heart journal2015

The effect of statin therapy on heart failure events: a collaborative meta-analysis of unpublished data from major randomized trials.

David Preiss et al.PubMed ↗Full text ↗Publisher ↗

What the trial testedrandomised · 1,000 people · 2015

Randomised comparison

Lowered adverse events & safety

−10%−16% to −3%

Bigger than 3 in 10 for adverse events & safety

As reported

RR 0.90, 95% CI 0.84–0.97

Randomised comparison

Lowered adverse events & safety

−8%−15% to −1%

Bigger than 3 in 10 for adverse events & safety

As reported

RR 0.92, 95% CI 0.85–0.99

Randomised comparison

Reduced cardiovascular events

−26%−30% to −22%

Bigger than 6 in 10 for cardiovascular events

As reported

RR 0.74, 95% CI 0.70–0.78

Range includes no effect

No clear effect on cardiovascular events

−3%−20% to +17%

Smaller than almost all for cardiovascular events

As reported

RR 0.97, 95% CI 0.80–1.17

+4 more in the walkthrough ↓

Eight numbers in the abstract

the abstract, start to end

0.90, 95% confidence interval, CI 0.84-0.97) and the composite HF outcome (1234/57 734 vs. 1344/57 836; RR 0.92, 95% CI 0.85-0.99) but not HF

whether this was preceded by MI (RR 0.87, 95% CI 0.68-1.11) or not (RR 0.91, 95% CI 0.84-0.98).

(213/57 734 vs. 220/57 836 events; RR 0.97, 95% CI 0.80-1.17) (Figure 2B).

238 vs. 1498/66 330 first events; RR 0.90, 95% CI 0.84-0.97) in 17 trials

734 vs. 1344/57 836 first events; RR 0.92, 95% CI 0.85-0.99) (Figure 2C).

first events in 65 530 on control; RR 0.74, 95% CI 0.70-0.78).

← favours treatmentfavours comparator →
could be chance
Adverse events & safety
RR 0.970.80–1.17
Adverse events & safety
RR 0.920.85–0.99
Adverse events & safety
RR 0.870.68–1.11
Adverse events & safety
RR 0.910.84–0.98
Cardiovascular events
RR 0.970.80–1.17
Adverse events & safety
RR 0.900.84–0.97
Adverse events & safety
RR 0.920.85–0.99
Cardiovascular events
RR 0.740.70–0.78
StatinsCardiovascular eventsAdverse events & safety

Statins × adverse events & safetyharms?mixed

unlikelylikely
0.16not counted

Statins × cardiovascular eventshelps?replicated

unlikelylikely
0.86not counted
← favours comparatorfavours treatment →
more certainless certain
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