← Statins × all-cause mortality

TrialCirculation. Heart failure2015

Association Between Use of Statins and Mortality in Patients With Heart Failure and Ejection Fraction of ≥50.

Urban Alehagen et al.PubMed ↗Publisher ↗

What the trial testedrandomised · 9,140 people · 2015

Randomised comparison

Reduced deaths

−20%−28% to −11%

Bigger than 6 in 10 for all-cause mortality

As reported

HR 0.80, 95% CI 0.72–0.89 · the paper's word: All-cause mortality

What moved togetherboth groups pooled, not the treatment’s effect

Correlation, not cause

Went with fewer cardiovascular events

−14%−25% to −2%

Bigger than 3 in 10 for cardiovascular events

As reported

HR 0.86, 95% CI 0.75–0.98

Correlation, not cause

Went with fewer cardiovascular events

−11%−18% to −4%

Bigger than 2 in 10 for cardiovascular events

As reported

HR 0.89, 95% CI 0.82–0.96

Three numbers in the abstract

the abstract, start to end

… for untreated patients (hazard ratio, 0.80; 95% confidence interval, …

… cardiovascular death (hazard ratio, 0.86; 95% confidence interval, 0.75-0.98; P=0.026) and composite all-cause mortality or cardiovascular hospitalization (hazard ratio, 0.89; 95% confidence interval, …

← favours treatmentfavours comparator →
could be chance
All-cause mortality
HR 0.800.72–0.89
Cardiovascular events
HR 0.860.75–0.98
Cardiovascular events
HR 0.890.82–0.96
StatinsCardiovascular eventsAll-cause mortality

Statins × all-cause mortalityhelps?mixed

unlikelylikely
0.500.50 without it
← favours comparatorfavours treatment →
this papermore certainless certain
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Full record →Abstract, authors, funding and every citing paper · PMID 26243795